- Clinafloxacin
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- $77.00 / 25mg
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2026-05-11
- CAS:105956-97-6
- Min. Order:
- Purity: 98.30%
- Supply Ability: 10g
- Clinafloxacin
-
- $77.00 / 25mg
-
2026-05-11
- CAS:105956-97-6
- Min. Order:
- Purity: 98.30%
- Supply Ability: 10g
- Clinafloxacin USP/EP/BP
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- $1.10 / 1g
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2025-11-18
- CAS:105956-97-6
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
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| | Clinafloxacin Basic information |
| Product Name: | Clinafloxacin | | Synonyms: | 3-Quinolinecarboxylic acid, 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-;6-Fluoro-8-chloro-1-cyclopropyl-7-(3-aminopyrrolidin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid;7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid;7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;CI-960;PD-127391;7-(3-Amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-8-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, monohydrochloride | | CAS: | 105956-97-6 | | MF: | C17H17ClFN3O3 | | MW: | 365.79 | | EINECS: | | | Product Categories: | | | Mol File: | 105956-97-6.mol |  |
| | Clinafloxacin Chemical Properties |
| Melting point | 253-258 C | | Boiling point | 592.3±50.0 °C(Predicted) | | density | 1.573±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | Acetic Acid (Slightly), DMSO (Slightly) | | pka | 6.39±0.50(Predicted) | | form | Solid | | color | Pale Beige | | InChI | InChI=1S/C17H17ClFN3O3/c18-13-14-10(5-12(19)15(13)21-4-3-8(20)6-21)16(23)11(17(24)25)7-22(14)9-1-2-9/h5,7-9H,1-4,6,20H2,(H,24,25) | | InChIKey | QGPKADBNRMWEQR-UHFFFAOYSA-N | | SMILES | N1(C2CC2)C2=C(C=C(F)C(N3CCC(N)C3)=C2Cl)C(=O)C(C(O)=O)=C1 | | CAS DataBase Reference | 105956-97-6(CAS DataBase Reference) | | EPA Substance Registry System | Clinafloxacin (105956-97-6) |
| | Clinafloxacin Usage And Synthesis |
| Uses | Antibacterial. | | Uses | Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV. | | Definition | ChEBI: 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-3-quinolinecarboxylic acid is a member of quinolines. | | in vivo | Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model.
With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis[3]. | | IC 50 | Quinolone |
| | Clinafloxacin Preparation Products And Raw materials |
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