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| | I-BET787 Basic information |
| Product Name: | I-BET787 | | Synonyms: | I-BET787;2(1H)-Pyridinone, 5-[4-chloro-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-imidazol-2-yl]-1,3-dimethyl- | | CAS: | 2201082-98-4 | | MF: | C16H20ClN3O2 | | MW: | 321.8 | | EINECS: | | | Product Categories: | | | Mol File: | 2201082-98-4.mol |  |
| | I-BET787 Chemical Properties |
| Boiling point | 512.380±60.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.328±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | DMSO: 2 mg/mL, clear | | form | Solid | | pka | 3.180±0.31(predicted) | | color | White to off-white |
| | I-BET787 Usage And Synthesis |
| Uses | I-BET787 is a pan-BET bromine domain inhibitor with oral activity. I-BET787 shows effectiveness in a mouse model of inflammation[1]. | | References | [1] Hirst DJ, et al. Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787. J Med Chem. 2024 Jun 27;67(12):10464-10489. DOI:10.1021/acs.jmedchem.4c00959 |
| | I-BET787 Preparation Products And Raw materials |
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