| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:STAT3-IN-35
CAS:2849535-96-0
Package:50mg/RMB 19800
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| | STAT3-IN-35 Basic information |
| Product Name: | STAT3-IN-35 | | Synonyms: | STAT3-IN-35;Naphtho[2′,1′:4,5]furo[2,3-c]pyridine-5,6-dione, 7,8,9,10-tetrahydro-9-[(1S)-1-(hydroxymethyl)-3-methylbutyl]- | | CAS: | 2849535-96-0 | | MF: | C21H23NO4 | | MW: | 353.41 | | EINECS: | | | Product Categories: | | | Mol File: | 2849535-96-0.mol |  |
| | STAT3-IN-35 Chemical Properties |
| Boiling point | 563.3±50.0 °C(predicted) | | density | 1.265±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 14.59±0.10(predicted) |
| | STAT3-IN-35 Usage And Synthesis |
| Uses | STAT3-IN-35 is a STAT3 inhibitor that binds to SH2 domain. STAT3-IN-35 inhibits the phosphorylation of STAT3 and possesses antiproliferative activities against triple-negative breast cancer (TNBC) cell lines. STAT3-IN-35 also has a toxicity and potent antitumor activity in a TNBC xenograft model[1]. | | References | [1] Fan C, et al. Natural Product-Inspired Discovery of Naphthoquinone-Furo-Piperidine Derivatives as Novel STAT3 Inhibitors for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2024 Sep 12;67(17):15291-15310. DOI:10.1021/acs.jmedchem.4c00872 |
| | STAT3-IN-35 Preparation Products And Raw materials |
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