PF-07957472

Request For Quotation
PF-07957472 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
PF-07957472 Basic information
Product Name:PF-07957472
Synonyms:PF-07957472;Benzamide, 2-methyl-5-(4-methyl-1-piperazinyl)-N-[1-[2-(1-methyl-1H-pyrazol-4-yl)-4-quinolinyl]cyclopropyl]-
CAS:3041047-51-9
MF:C29H32N6O
MW:480.61
EINECS:
Product Categories:
Mol File:3041047-51-9.mol
PF-07957472 Structure
PF-07957472 Chemical Properties
Boiling point 709.0±60.0 °C(predicted)
density 1.28±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka13.07±0.20(predicted)
Safety Information
MSDS Information
PF-07957472 Usage And Synthesis
UsesPF-07957472 (Compound 4) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor. PF-07957472 shows cytopathic effect in SARS-CoV-2 infected NHBE cells (EC50 = 13.9 nM). PF-07957472 shows antiviral effect in a mouse-adapted model of COVID-19 infection model[1].
References[1] Garnsey MR, et al. Discovery of SARS-CoV-2 papain-like protease (PLpro) inhibitors with efficacy in a murine infection model. Sci Adv. 2024 Aug 30;10(35):eado4288. DOI:10.1126/sciadv.ado4288
PF-07957472 Preparation Products And Raw materials
Tag:PF-07957472(3041047-51-9) Related Product Information
Brequinar SARS-CoV-2 3CLpro/3C-like protease protein SARS-COV-2 S protein RBD (194A.A, HEK293, HIS) SARS-COV-2 S protein RBD (HEK293, FC) SARS-COV-2 S protein RBD (N501Y, K417N, E484K, HEK293, HIS) SARS-CoV-2 S1 protein (HEK293)