| Company Name: |
TargetMol |
| Tel: |
400-821-0310 15002144251 |
| Email: |
xuexiang.shao@tsbiochem.com |
|
| | PLpro-IN-3 Basic information |
| Product Name: | PLpro-IN-3 | | Synonyms: | PLpro-IN-3;2-Thiophenecarboxylic acid, 5-[[[5-[5-[1-(2-fluoro[1,1′-biphenyl]-4-yl)ethyl]-1,2,4-oxadiazol-3-yl]-2-methylphenyl]amino]methyl]- | | CAS: | 3047093-72-8 | | MF: | C29H24FN3O3S | | MW: | 513.58 | | EINECS: | | | Product Categories: | | | Mol File: | 3047093-72-8.mol |  |
| | PLpro-IN-3 Chemical Properties |
| Boiling point | 719.3±70.0 °C(predicted) | | density | 1.321±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 3.56±0.10(predicted) |
| | PLpro-IN-3 Usage And Synthesis |
| Uses | PLpro-IN-3 (compound 26R) is a potent Papain-like protease (PLpro) inhibitor with a IC50 of 1.0μM. PLpro-IN-3 exhibits antiviral activity against SARS-CoV-2 with a EC50 of 4.3 μM[1]. | | References | [1] Qin B, et al. Design, Synthesis, and Biological Evaluation of 1,2,4-Oxadiazole Derivatives Containing an Aryl Carboxylic Acid Moiety as Potent Sarbecovirus Papain-like Protease Inhibitors. J Med Chem. 2024 Jun 27;67(12):10211-10232. DOI:10.1021/acs.jmedchem.4c00534 |
| | PLpro-IN-3 Preparation Products And Raw materials |
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