(3-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER manufacturers
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| | (3-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER Basic information |
| Product Name: | (3-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER | | Synonyms: | tert-butyl 3-formylphenylcarbamate;(3-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER;tert-butylN-(3-formylphenyl)carbamate;3-(tert-Butoxycarbonylamino)benzaldehyde;3-(BOC-AMino)benzaldehyde;Carbamic acid, N-(3-formylphenyl)-, 1,1-dimethylethyl ester | | CAS: | 176980-36-2 | | MF: | C12H15NO3 | | MW: | 221.25 | | EINECS: | | | Product Categories: | | | Mol File: | 176980-36-2.mol |  |
| | (3-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties |
| Melting point | 88℃ | | Boiling point | 291℃ | | density | 1.163 | | Fp | 130℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | solid | | pka | 13.50±0.70(Predicted) | | color | Beige |
| RIDADR | UN2811 | | HS Code | 2913000090 |
| | (3-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER Usage And Synthesis |
| Synthesis | General procedure for the synthesis of tert-butyl (3-formylphenyl)-carbamate from tert-butyl (3-(hydroxymethyl)phenyl)carbamate: activated manganese dioxide (7.8 g, 90 mmol) was added to a solution of dichloromethane (50 mL) containing 3-(tert-butoxycarbonylamino)-benzyl alcohol (2.0 g, 9.0 mmol). The resulting suspension was stirred and reacted at room temperature for 16 hours. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to give 1.7 g (85% yield) of the target product. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 9.97 (s, 1H), 7.92 (t, J = 1.8 Hz, 1H), 7.63 (dd, J = 8.0,1.1 Hz, 1H), 7.55 (ddd, J = 7.6,1.4,1.1 Hz, 1H), 7.44 (t, J = 7.6 Hz, 1H), and 1.53 (s, 9H). | | References | [1] Chemistry - A European Journal, 2016, vol. 22, # 26, p. 8814 - 8822
[2] Angewandte Chemie - International Edition, 2017, vol. 56, # 49, p. 15746 - 15750
[3] Angew. Chem., 2017, vol. 129, p. 15952 - 15957,6
[4] Patent: WO2018/114965, 2018, A1. Location in patent: Page/Page column 27
[5] Chemistry of Materials, 2011, vol. 23, # 21, p. 4844 - 4856 |
| | (3-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials |
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