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| | LAMP-1/CD107a Rabbit Monoclonal Antibody (Clone 107) Basic information |
| | LAMP-1/CD107a Rabbit Monoclonal Antibody (Clone 107) Chemical Properties |
| | LAMP-1/CD107a Rabbit Monoclonal Antibody (Clone 107) Usage And Synthesis |
| Description | Lysosome-associated membrane protein 1 (LAMP-1), also known as CD107a, is an abundant lysosomal integral membrane glycoprotein.1 It is composed of a signal peptide, two LAMP-like domains that are separated by a proline-rich hinge region, a transmembrane domain, and a C-terminal tail that contains a YXXI tyrosine-based motif, which is required for targeting of LAMP-1 to the lysosome.1,2 LAMP-1 is ubiquitously expressed and localizes to lysosomes, endosomes, and the plasma membrane.1,2 It is involved in human peripheral blood mononuclear cells (PBMC) adhesion to vascular endothelium, natural killer (NK) cell degranulation, virus entry, and cancer progression and metastasis.3,4,5,6 Homozygous knockout of Lamp1 prevents Lassa virus infection in mice.5 Pulmonary protein levels of LAMP-1 are increased in patients with chronic obstructive pulmonary disease (COPD), and increased LAMP-1 lung levels positively correlate with smoking history and negatively correlate with lung function.7 Cayman’s LAMP-1/CD107a Rabbit Monoclonal Antibody (Clone 107) can be used for ELISA, flow cytometry (FC), immunocytochemistry (ICC), immunofluorescence (IF), immunohistochemistry paraffin (IHC-P), immunoprecipitation (IP), and Western blot (WB) applications. The antibody recognizes LAMP-1 at 120 kDa from human samples.WARNING This product is not for human or veterinary use. |
| | LAMP-1/CD107a Rabbit Monoclonal Antibody (Clone 107) Preparation Products And Raw materials |
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