Myelin Basic Protein Peptide Antagonist (trifluoroacetate salt)

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Myelin Basic Protein Peptide Antagonist (trifluoroacetate salt) Suppliers list
Company Name: Cayman Chemical Company  
Tel: 800-364-9897
Email: sales@caymanchem.com
Company Name: Neobioscience Co., Ltd.  
Tel: 4006-800-892
Email: info@neobioscience.com
Myelin Basic Protein Peptide Antagonist (trifluoroacetate salt) Basic information
Product Name:Myelin Basic Protein Peptide Antagonist (trifluoroacetate salt)
Synonyms:Myelin Basic Protein Peptide Antagonist (trifluoroacetate salt)
CAS:
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
Myelin Basic Protein Peptide Antagonist (trifluoroacetate salt) Structure
Myelin Basic Protein Peptide Antagonist (trifluoroacetate salt) Chemical Properties
solubility DMF: 1 mg/ml
DMSO: 3 mg/ml
Ethanol: insolPBS (pH 7.2): 5 mg/ml
Safety Information
MSDS Information
Myelin Basic Protein Peptide Antagonist (trifluoroacetate salt) Usage And Synthesis
DescriptionMyelin basic protein (MBP) peptide antagonist is a synthetic peptide antagonist against the multiple sclerosis (MS) autoantigen MBP.1 MBP peptide antagonist binds to the immunomodulatory region of MBP, corresponding to residues 85-99 and inhibits MBP binding to human HLA-DR2 in a concentration-dependent manner. It inhibits the production of IL-2 in T cell hybridoma cells expressing an MBP (85-99)-specific T cell receptor derived from a patient with multiple sclerosis. MBP peptide antagonist also delays MBP (85-99)-induced experimental autoimmune encephalomyelitis (EAE) onset and reduces EAE symptom severity in double-transgenic humanized mice expressing human HLA-DR2 and MBP (85-99)-specific T cell receptor antigen in a model of MS when administered at a dose of 100 µg/animal.WARNING This product is not for human or veterinary use.
References[1] JOEL N H STERN. Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 5: 1620-1625. DOI: 10.1073/pnas.0409022102
Myelin Basic Protein Peptide Antagonist (trifluoroacetate salt) Preparation Products And Raw materials
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