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| | 2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine Basic information | | Uses |
| Product Name: | 2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine | | Synonyms: | 2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine;Thieno[3,2-d]pyriMidine, 2,4-dichloro-7-Methyl-;2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine-3;2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine ISO 9001：2015 REACH | | CAS: | 35265-83-9 | | MF: | C7H4Cl2N2S | | MW: | 219.09 | | EINECS: | | | Product Categories: | Heterocycle-Pyrimidine series | | Mol File: | 35265-83-9.mol | ![2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine Structure](CAS/GIF/35265-83-9.gif) |
| | 2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine Chemical Properties |
| Boiling point | 293℃ | | density | 1.568 | | Fp | 131℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -0.48±0.40(Predicted) | | Appearance | White to off-white Solid | | InChI | InChI=1S/C7H4Cl2N2S/c1-3-2-12-5-4(3)10-7(9)11-6(5)8/h2H,1H3 | | InChIKey | WUXYWALKGQDXFI-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC(Cl)=C2SC=C(C)C2=N1 |
| | 2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine Usage And Synthesis |
| Uses | 2,4-Dichloro-7-methylthiopheno[3,2-D]pyrimidine is a heterocyclic derivative that can be used as an intermediate in organic synthesis. | | Synthesis | GENERAL STEPS: 7-methylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (89.4 g) was added to a solution of acetonitrile (450 mL) containing phosphorochloridic acid (312 g, 2.04 mol), and N,N-dimethylaniline (44.6 g, 0.368 mol) over 10 minutes. The reaction mixture was heated to 85°C and stirred at this temperature for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and then slowly poured into a mixture of ice (900 g) and water (300 mL) while controlling the temperature below 10°C. Stirring was continued at this temperature for 30 minutes. The resulting solid product was collected by filtration, washed with water (450 mL) and subsequently dried under reduced pressure at 50 °C for 24 h to afford the target compound 2,4-dichloro-7-methylthieno[3,2-d]pyrimidine (97.0 g, 90% yield). The product was a white solid and its structure was confirmed by 1H NMR (400 MHz, CDCl3) δ 7.75 (s, 1H), 2.50 (s, 3H) and LCMS (ESI pos) m/z [M+H] 220. | | References | [1] Patent: US2014/100366, 2014, A1. Location in patent: Page/Page column
[2] Patent: WO2008/58285, 2008, A2. Location in patent: Page/Page column 51
[3] Patent: US2001/6969, 2001, A1
[4] Patent: US6339089, 2002, B2. Location in patent: Referential example 17
[5] European Journal of Medicinal Chemistry, 2011, vol. 46, # 1, p. 71 - 76 |
| | 2,4-Dichloro-7-methylthieno[3,2-d]pyrimidine Preparation Products And Raw materials |
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