- 4-(Boc-amino)pyridine
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- $1.10 / 1g
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2025-11-18
- CAS:98400-69-2
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
- 4-(Boc-amino)pyridine
-
- $1.00 / 1g
-
2019-12-20
- CAS:98400-69-2
- Min. Order: 1g
- Purity: 99%
- Supply Ability: g/kg/T
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| | 4-(Boc-amino)pyridine Basic information |
| | 4-(Boc-amino)pyridine Chemical Properties |
| Melting point | 145-149 °C | | Boiling point | 252.7±13.0 °C(Predicted) | | density | 1.131±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | powder to crystal | | pka | 12+-.0.70(Predicted) | | color | White to Almost white | | InChI | InChI=1S/C10H14N2O2/c1-10(2,3)14-9(13)12-8-4-6-11-7-5-8/h4-7H,1-3H3,(H,11,12,13) | | InChIKey | DRZYCRFOGWMEES-UHFFFAOYSA-N | | SMILES | C(OC(C)(C)C)(=O)NC1C=CN=CC=1 |
| Hazard Codes | Xn | | Risk Statements | 22-43 | | Safety Statements | 36/37 | | WGK Germany | 3 | | HS Code | 29333990 |
| | 4-(Boc-amino)pyridine Usage And Synthesis |
| Chemical Properties | White to light brown solid | | Uses | 4-(Boc-amino)pyridine is a protected derivative of the amino acid Pyridine, a heterocyclic compound that is commonly found in biological specimens (such as human red blood cells), and is used as a starting reagent and intermediate in the chemical and pharmaceutical industries. | | Synthesis | At room temperature, 4-aminopyridine (600 mg, 6.36 mmol), 4-dimethylaminopyridine (DMAP, 600 μg, 5.00 μmol), di-tert-butyl dicarbonate (Boc2O, 1.57 mL, 7.00 mmol) and triethylamine (Et3N, 1 mL, 7.63 mmol) were suspended in anhydrous tetrahydrofuran (THF, 3 mL) in anhydrous tetrahydrofuran (THF, 3 mL) and the reaction was stirred under argon protection for 20 min. After completion of the reaction, the reaction mixture was diluted with dichloromethane (CH2Cl2, 5 mL) and washed with 0.1 N hydrochloric acid (5 mL). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated by rotary evaporation. Finally, the target product 4-(tert-butoxycarbonylamino)pyridine (S1w, 1.30 g, yield >99%) was purified as a white solid by column chromatography (eluent ratio 30:1 dichloromethane/methanol). | | References | [1] Tetrahedron Letters, 2006, vol. 47, # 7, p. 1087 - 1091
[2] Organic and Biomolecular Chemistry, 2006, vol. 4, # 14, p. 2769 - 2771
[3] Chemistry Letters, 2010, vol. 39, # 11, p. 1127 - 1129
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 9, p. 2114 - 2124
[5] Tetrahedron Letters, 2007, vol. 48, # 47, p. 8318 - 8322 |
| | 4-(Boc-amino)pyridine Preparation Products And Raw materials |
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