|
|
| | 8-AMINO-6-METHOXYQUINOLINE Basic information |
| | 8-AMINO-6-METHOXYQUINOLINE Chemical Properties |
| Melting point | 41 °C | | Boiling point | 137-138 °C(Press: 1 Torr) | | density | 1.217±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 3.49±0.10(Predicted) | | color | Brown to Very Dark Brown | | Stability: | Incompatible with strong oxidizing agents. | | CAS DataBase Reference | 90-52-8(CAS DataBase Reference) |
| HazardClass | IRRITANT | | HS Code | 2933499090 |
| | 8-AMINO-6-METHOXYQUINOLINE Usage And Synthesis |
| Chemical Properties | solid | | Uses | 8-Amino-6-methoxyquinoline has oxidizing properties as well as potential anti-tuberculosis application with its antimycobacterial messages as well. | | Synthesis | 8-Amino-6-methoxyquinoline can be obtained by reducing 6-methoxy-8-nitroquinoline with iron powder in hydrochloric acid medium and then neutralizing it with liquid base. The steps are as follows: Put hydrochloric acid into a glass-lined reaction pot, raise the temperature to 50C, put in 6-methoxy-8-nitroquinoline and iron powder. At 65-70 in 3.5h all added, holding 2h, cooling, filtration of crude 8-amino-6-methoxyquinoline hydrochloride. Then it was refined by salting out, neutralized to pH 7 with dilute base, precipitated 8-amino-6-methoxyquinoline, filtered to get the crude product, and refined with toluene to get the final product. | | Purification Methods | Distil it under N2 and at high vacuum, then recrystallise it several times from MeOH (0.4mL/g). It remains colourless for several months when purified in this way [Elderfield & Rubin J Am Chem Soc 75 2963 1953]. The hydrobromide [312693-53-1] M 255.1 has m 238o(dec). [Beilstein 22 III/IV 5934.] |
| | 8-AMINO-6-METHOXYQUINOLINE Preparation Products And Raw materials |
|