Coumarin 106 manufacturers
- Coumarin 106
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2026-06-30
- CAS:41175-45-5
- Min. Order: 1KG
- Purity: 98.0%
- Supply Ability: 10000KGS
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| | Coumarin 106 Basic information |
| Product Name: | Coumarin 106 | | Synonyms: | 11-hexahydro-;1h,5h-cyclopenta[3,4][1]benzopyrano[6,7,8-ij]quinolizin-12(9h)-one,2,3,6,7,10,;COUMARIN 106;COUMARIN 478;Coumarin106,lasergrade;Exciton Coumarin 478;COUMARIN 106, LASER GRADE, PURE;Coumarin 106,pure,laser grade | | CAS: | 41175-45-5 | | MF: | C18H19NO2 | | MW: | 281.35 | | EINECS: | 255-246-3 | | Product Categories: | | | Mol File: | 41175-45-5.mol |  |
| | Coumarin 106 Chemical Properties |
| Melting point | 149 °C | | Boiling point | 538.4±50.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | solubility | DMSO: Slightly soluble: 0.1-1 mg/ml | | pka | 6.38±0.20(Predicted) | | form | powder to crystal | | color | Light orange to Yellow to Green | | λmax | 375nm(Acetone)(lit.) | | EPA Substance Registry System | 1H,5H-Cyclopenta[3,4][1]benzopyrano[6,7,8-ij]quinolizin-12(9H)-one, 2,3,6,7,10,11-hexahydro- (41175-45-5) |
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ACROS
| English |
| | Coumarin 106 Usage And Synthesis |
| Description | Coumarin 478 is a vital chemical compound used in biomedicine mainly for its anticancer properties. It has demonstrated potential in inhibiting tumor growth and metastasis, making it a valuable drug in the treatment of various types of cancers. Coumarin 478 shows promising results in clinical trials and is actively being researched for its effectiveness against specific cancer types. | | Chemical Properties | yellow powder and chunks | | Uses | Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC50=4.97 and Ki=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC50=4.56)[1][2]. | | References | [1] Patil SK, et al. Determination of ground and excited state dipole moments of dipolar laser dyes by solvatochromic shift method. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Apr 5;123:117-26. DOI:10.1016/j.saa.2013.12.031
[2] Fallarero A, et al. Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106. Pharmacol Res. 2008 Sep-Oct;58(3-4):215-21. DOI:10.1016/j.phrs.2008.08.001
[3] G.A. REYNOLDS K. H D. New coumarin dyes with rigidized structure for flashlamp-pumped dye lasers[J]. Optics Communications, 1975, 13 3: Pages 222-225. DOI: 10.1016/0030-4018(75)90085-1
[4] EMMA ALEXANDER. Room temperature phosphorescence of coumarin 106 with direct triplet state excitation[J]. Dyes and Pigments, 2023, 217: Article 111389. DOI: 10.1016/j.dyepig.2023.111389 |
| | Coumarin 106 Preparation Products And Raw materials |
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