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Balicatib

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Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:Balicatib
CAS:354813-19-7
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: career henan chemical co
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Products Intro: Product Name:Balicatib
CAS:354813-19-7
Purity:99% Package:5KG;5USD
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Products Intro: Product Name:Balicatib
CAS:354813-19-7
Purity:98% HPLC LCMS Package:10G;20G
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Balicatib
CAS:354813-19-7
Purity:98.09% Package:5mg;34USD|10mg;61USD|25mg;141USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Baoji Guokang Healthchem Co., Ltd.
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Products Intro: Product Name:Balicatib
CAS:354813-19-7
Purity:0.99 Package:5KG;1KG

Balicatib manufacturers

  • Balicatib
  • Balicatib pictures
  • $56.00 / 5mg
  • 2026-04-22
  • CAS:354813-19-7
  • Min. Order:
  • Purity: 98.00%
  • Supply Ability: 10g
  • Balicatib
  • Balicatib pictures
  • $15.00 / 1KG
  • 2021-07-13
  • CAS:354813-19-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Balicatib
  • Balicatib pictures
  • $15.00 / 1KG
  • 2021-07-10
  • CAS:354813-19-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Balicatib Basic information
Product Name:Balicatib
Synonyms:Balicatib;Balicatib, AAE-581;N-(1-(CYANOMETHYLCARBAMOYL)CYCLOHEXYL)-4-(4-PROPYLPIPERAZIN-1-YL)BENZAMIDE;AAE-581;Balicatib N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide;N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide Balicatib(AAE-581);Balicatib, >=98%;AAE581; AAE 581; AAE-581
CAS:354813-19-7
MF:C23H33N5O2
MW:411.54
EINECS:200-256-5
Product Categories:Inhibitors
Mol File:354813-19-7.mol
Balicatib Structure
Balicatib Chemical Properties
Boiling point 687.4±55.0 °C(Predicted)
density 1.19±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:52.04(Max Conc. mg/mL);126.45(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);60.75(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.21(Max Conc. mM)
Ethanol:1.75(Max Conc. mg/mL);4.25(Max Conc. mM)
form A crystalline solid
pka13.23±0.20(Predicted)
color White to off-white
InChIInChI=1S/C23H33N5O2/c1-2-14-27-15-17-28(18-16-27)20-8-6-19(7-9-20)21(29)26-23(10-4-3-5-11-23)22(30)25-13-12-24/h6-9H,2-5,10-11,13-18H2,1H3,(H,25,30)(H,26,29)
InChIKeyLLCRBOWRJOUJAE-UHFFFAOYSA-N
SMILESC(NC1(C(NCC#N)=O)CCCCC1)(=O)C1=CC=C(N2CCN(CCC)CC2)C=C1
Safety Information
MSDS Information
Balicatib Usage And Synthesis
UsesBalicatib is a potent inhibitor of Cathepsin K (Cat K), a lysosomal cysteine protease, for the treatment of osteoporosis.
in vivo

Balicatib (0, 3, 10, 50 mg/kg; Oral gavage; twice daily for 18 months) partially prevented ovariectomyinduced changes in bone mass, inhibited bone turnover at most sites, and had an stimulatory effect on periosteal bone formation in cynomolgus monkeys[1].

Animal Model:11-13 years, female cynomolgus monkeys (Macaca fascicularis)[1]
Dosage:0, 3, 10, 50 mg/kg
Administration:Oral gavage; twice daily for 18 months
Result:Completely prevented ovariectomy-induced increases in BFR/BS in cancellous bone of vertebra and femur and in osteonal and endocortical bone of vertebra, significantly decreased bone formation rates.
IC 50cathepsin K: 22 nM (IC50); cathepsin L: 48 nM (IC50); Cathepsin B: 61 nM (IC50); cathepsin S: 2900 nM (IC50)
storageStore at -20°C
Balicatib Preparation Products And Raw materials
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