| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:N-BroMoacetyl-β-alanine
CAS:89520-11-6
Package:2.5g,250Mg
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| | N-Bromoacetyl--alanine Basic information |
| | N-Bromoacetyl--alanine Chemical Properties |
| Melting point | 71-77°C | | Boiling point | 433.4±30.0 °C(Predicted) | | density | 1.682±0.06 g/cm3(Predicted) | | solubility | Dichloromethane | | form | Pale Yellow Semi-Solid | | pka | 4.27±0.10(Predicted) |
| | N-Bromoacetyl--alanine Usage And Synthesis |
| Description | 3-(2-bromoacetamido)propanoic acid is a compound containing a bromide group and a terminal carboxylic acid. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Chemical Properties | Pale Yellow Semi-Solid | | Uses | N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. | | IC 50 | Alkyl-Chain; Cleavable Linker | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
[2] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
| | N-Bromoacetyl--alanine Preparation Products And Raw materials |
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