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| | (D-Trp12,Tyr34)-PTH (7-34) amide (bovine) Basic information |
| Product Name: | (D-Trp12,Tyr34)-PTH (7-34) amide (bovine) | | Synonyms: | H-PHE-MET-HIS-ASN-LEU-D-TRP-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-TYR-NH2;THYROID, BOVINE;(D-Trp12,Tyr34)-pTH (7-34) amide;PHE-MET-HIS-ASN-LEU-D-TRP-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-TYR-NH2;D-Trp12,Tyr34]-bPTH-(7-34)NH2;(D-Trp??,Tyr??)-pTH (7-34) amide (bovine) trifluoroacetate salt;DTrp12, Tyr34]-pTH(7-34), -Parathyroid Hor;DTrp12, Tyr34]-Parathyroid Hormone(7-34), -Parath | | CAS: | 118102-98-0 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![(D-Trp12,Tyr34)-PTH (7-34) amide (bovine) Structure]() |
| | (D-Trp12,Tyr34)-PTH (7-34) amide (bovine) Chemical Properties |
| storage temp. | -15°C | | solubility | Soluble in DMSO | | form | Solid | | color | White to off-white | | Sequence | Phe-Met-His-Asn-Leu-{d-Trp}-Lys-His-Leu-Ser-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Tyr-NH2 |
| | (D-Trp12,Tyr34)-PTH (7-34) amide (bovine) Usage And Synthesis |
| Uses | (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki of 69 nM in bovine renal cortical membrane. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) can be used for growth and development regulation[1][2]. | | in vivo | (D-Trp12,Tyr34)-pTH (7-34) amide (1 mg/mL once, 0.1 mg/mL for 6 h; i.v.) has no significant effect on serum calcium levels in hypercalcemic athymic nude mice bearing a human squamous cell carcinoma of the lung[3]. | | References | [1] Goldma ME, et, al. A new highly potent parathyroid hormone antagonist: [D-Trp12,Tyr34]bPTH-(7-34)NH2. Endocrinology. 1988 Nov; 123(5): 2597-9. DOI:10.1210/endo-123-5-2597
[2] Pizurki L, et, al. Inhibition by (D-Trp12,Tyr34)bPTH(7-34)amide of PTH and PTHrP effects on Pi transport in renal cells. Am J Physiol. 1990 Aug; 259(2 Pt 2): F389-92. DOI:10.1152/ajprenal.1990.259.2.F389
[3] Kukreja SC, Inactivation by plasma may be responsible for lack of efficacy of parathyroid hormone antagonists in hypercalcemia of malignancy. Endocrinology. 1994 May; 134(5): 2184-8. DOI:10.1210/endo.134.5.8156920 |
| | (D-Trp12,Tyr34)-PTH (7-34) amide (bovine) Preparation Products And Raw materials |
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