N-(4-{2-[3-(trifluoromethyl)anilino]-1,3-thiazol-4-yl}phenyl)acetamide

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N-(4-{2-[3-(trifluoromethyl)anilino]-1,3-thiazol-4-yl}phenyl)acetamide Basic information
Product Name:N-(4-{2-[3-(trifluoromethyl)anilino]-1,3-thiazol-4-yl}phenyl)acetamide
Synonyms:N-(4-{2-[3-(trifluoromethyl)anilino]-1,3-thiazol-4-yl}phenyl)acetamide;Acetamide, N-[4-[2-[[3-(trifluoromethyl)phenyl]amino]-4-thiazolyl]phenyl]-;Todalam/MS-7520;Tubulin inhibitor 49;Todalam
CAS:1023875-75-3
MF:C18H14F3N3OS
MW:377.38
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Mol File:1023875-75-3.mol
N-(4-{2-[3-(trifluoromethyl)anilino]-1,3-thiazol-4-yl}phenyl)acetamide Structure
N-(4-{2-[3-(trifluoromethyl)anilino]-1,3-thiazol-4-yl}phenyl)acetamide Chemical Properties
density 1.397±0.06 g/cm3(Predicted)
pka14.58±0.70(Predicted)
Safety Information
MSDS Information
N-(4-{2-[3-(trifluoromethyl)anilino]-1,3-thiazol-4-yl}phenyl)acetamide Usage And Synthesis
UsesTubulin inhibitor 49 (Compound 18) is an inhibitor for tubulin polymerization with an IC50 of 48 μM. Tubulin inhibitor 49 disrupts the cell microtubule network, arrests the cell cycle at G2 phase, and exhibits cytotoxicity (IC50=8.8 μM in HeLa cell)[1].
References[1] Mühlethaler T, et al., Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action. Angew Chem Int Ed Engl. 2022 Jun 20;61(25):e202204052. DOI:10.1002/anie.202204052
N-(4-{2-[3-(trifluoromethyl)anilino]-1,3-thiazol-4-yl}phenyl)acetamide Preparation Products And Raw materials
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