(R)-(+)-SKF-38393 hydrochloride

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(R)-(+)-SKF-38393 hydrochloride manufacturers
(R)-(+)-SKF-38393 hydrochloride Basic information
Product Name:(R)-(+)-SKF-38393 hydrochloride
Synonyms:R(+)-SKF-38393 HYDROCHLORIDE;R-SKF-38393A HCl;RSKF38393A HCl,R SKF 38393A HCl;(R)-(+)-SKF38393 hydrochloride, D1 partial agonist;(R)-(+)-SKF-38393 hydrochloride
CAS:81702-42-3
MF:C16H17NO2.ClH
MW:291.776
EINECS:
Product Categories:
Mol File:81702-42-3.mol
(R)-(+)-SKF-38393 hydrochloride Structure
(R)-(+)-SKF-38393 hydrochloride Chemical Properties
Melting point 244-246 °C
storage temp. -20°C
solubility 0.1 M HCl: soluble1.2mg/mL
form solid
color off-white to light tan
Optical Rotation[α]22/D +16.1°, c = 1.2 in methanol(lit.)
Water Solubility water: 100mM
InChI1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1
InChIKeyYEWHJCLOUYPAOH-PFEQFJNWSA-N
SMILESCl.Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-22
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
(R)-(+)-SKF-38393 hydrochloride Usage And Synthesis
Uses(R)-(+)-SKF-38393 Hydrochloride is the active enantiomer of (±)-SKF-38393, a D1 dopamine receptor agonist.
Uses(R)-(+)-SKF-38393 hydrochloride has been used as a D1 dopamine receptor agonist to study its effect on the sleep-wake pattern of macaques rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Biochem/physiol Actions(R)-(+)-SKF-38393 hydrochloride is a D1 dopamine receptor agonist and an active enantiomer of (±)-SKF-38393. It enhances pertussis toxin-insensitive and protein kinase A-mediated glutamate release in the hippocampal neurons. SKF-38393, abenzazepine derivative, exhibits anorectic effects.
(R)-(+)-SKF-38393 hydrochloride Preparation Products And Raw materials
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