丙环定盐酸盐
| 中文名称 | 丙环定盐酸盐 |
|---|---|
| 中文同义词 | 丙环定盐酸盐;1-苯基-1-环己基-3-吡咯烷丙醇盐酸盐;卡马特灵;开马君;盐酸丙环定 USP标准品;盐酸丙环利定;丙环定盐酸盐,10 MM DMSO 溶液 |
| 英文名称 | PROCYCLIDINE HYDROCHLORIDE |
| 英文同义词 | a-Cyclohexyl-a-phenyl-1-pyrrolidinepropanol hydrochloride;alpha-cyclohexyl-alpha-phenyl-1-pyrrolidinepropanomonohydrochloride;kemadrin;kemadrinhydrochloride;PROCYCLIDINE HCL;PROCYCLIDINE HYDROCHLORIDE;ALPHA-CYCLOHEXYL-ALPHA-PHENYL-1-PYRROLIDINEPROPANOL HYDROCHLORIDE;α-Cyclohexyl-α-phenyl-1-pyrrolidinepropanol |
| CAS号 | 1508-76-5 |
| 分子式 | C19H30ClNO |
| 分子量 | 323.9 |
| EINECS号 | 216-141-8 |
| 相关类别 | 原料药;KEMADRIN;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals |
| Mol文件 | 1508-76-5.mol |
| 结构式 |  |
丙环定盐酸盐 性质
| 熔点 | 159-164 °C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 氯仿（微溶）、甲醇（微溶）、水（微溶） |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 主要应用 | pharmaceutical (small molecule) |
| InChI | 1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H |
| InChIKey | ZFSPFXJSEHCTTR-UHFFFAOYSA-N |
| SMILES | Cl.OC(CCN1CCCC1)(C2CCCCC2)c3ccccc3 |
Procyclidine hydrochloride 是一种有效的抗胆碱能试剂，也具有NMDA拮抗剂的特性。
NMDA Receptor
Procyclidine widely used as anti-parkinsonian agents because of their anti-cholinergic action, is also known to have NMDA antagonist properties. Unlike other NMDA antagonists, these agents-because of their anti-cholinergic action-are devoid of neurotoxic side effects. Procyclidine alleviates thermal hyperalgesia in a dose dependent manner; when a marginally effective dose of the agent is combined with an ineffective dose of an alpha(2) adrenergic agonist (Clonidine or Guanabenz), the combination therapy provides effective and long-lasting relief from neuropathic pain.
用途
An anticholinergic drug used in the treatment parkinson鈥檚 disease. It is also used to treat patients suffering from drug-induced parkinsonism, akathisia and acute dystonia.安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 20/21/22 |
| 安全说明 | 36 |
| WGK Germany | 3 |
| RTECS号 | UY1926000 |
| 海关编码 | 2933997500 |
| 存储类别 | 11 - 可燃固体 |
| 毒性 | mouse,LD50,intravenous,14mg/kg (14mg/kg),BEHAVIORAL: TREMORLUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 383, 1955. |
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