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| | 4-METHYLPYRAZOLE-5-CARBOXYLIC ACID Basic information | | Uses |
| Product Name: | 4-METHYLPYRAZOLE-5-CARBOXYLIC ACID | | Synonyms: | 4-METHYLPYRAZOLE-5-CARBOXYLIC ACID;4-Methyl-1H-pyrazole-3-carboxylic acid;4-methyl-1H-pyrazole-5-carboxylic acid;4-Methylpyrazole-3-carboxylic Acid;1H-Pyrazole-3-carboxylic acid, 4-methyl- | | CAS: | 82231-51-4 | | MF: | C5H6N2O2 | | MW: | 126.11 | | EINECS: | | | Product Categories: | | | Mol File: | 82231-51-4.mol |  |
| | 4-METHYLPYRAZOLE-5-CARBOXYLIC ACID Chemical Properties |
| Boiling point | 389.2±22.0 °C(Predicted) | | density | 1.404±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 15.75±0.50(Predicted) | | Appearance | White to off-white Solid |
| | 4-METHYLPYRAZOLE-5-CARBOXYLIC ACID Usage And Synthesis |
| Uses | 4-Methylpyrazole-3-carboxylic Acid is a useful research chemical. | | Definition | ChEBI: 4-methyl-pyrazole-3-carboxylic acid is a memebr of the class of pyrazoles that is 1H-pyrazole with methyl and carboxylic acid group substituents at positions 4 and 3 respectively. It has a role as a metabolite. It is a member of pyrazoles and a monocarboxylic acid. It derives from a hydride of a 1H-pyrazole. | | Synthesis | Ethyl 4-methyl-5-trimethylsilylpyrazole-3-carboxylate (3.3 g, 14.6 mmol) was dissolved in ethanol (100 mL) and 1 M aqueous sodium hydroxide (73 mL, 73 mmol). The reaction mixture was heated to reflux for 18 hours and subsequently cooled to room temperature. The reaction solution was acidified with 1 M hydrochloric acid (100 mL) and concentrated to near dryness. The residue was extracted with ethyl acetate (3 x 100 mL), the organic phases were combined, dried over anhydrous sodium sulfate, and concentrated to give 4-methylpyrazole-3-carboxylic acid (1.90 g, 99% yield). The product was confirmed by NMR hydrogen spectrum (DMSO-d6, 400 MHz): δ 13.00 (broad single peak, 2H), 7.50 (single peak, 1H), 2.19 (single peak, 3H). | | References | [1] Patent: WO2006/32851, 2006, A1. Location in patent: Page/Page column 69-70; 73 |
| | 4-METHYLPYRAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials |
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