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| | 2,6-Dichloro-7-methylpurine Basic information |
| Product Name: | 2,6-Dichloro-7-methylpurine | | Synonyms: | 106282;2,6-Dichloro-7-methyl-7h-purine ,98%;2,6-DICHLORO-7-METHYLPURINE;2,6-DICHLORO-7-METHYL-7H-PURINE;7H-Purine, 2,6-dichloro-7-methyl-;2,6-dichloro-7-methyl-purin;2,6-DICHLORO-7-METHYLPURINE 97% (HPLC);2,6-DICHLORO-7-METHYLPURINE (2,6DCl7MeP) | | CAS: | 2273-93-0 | | MF: | C6H4Cl2N4 | | MW: | 203.03 | | EINECS: | | | Product Categories: | | | Mol File: | 2273-93-0.mol |  |
| | 2,6-Dichloro-7-methylpurine Chemical Properties |
| Melting point | 195.5-196 °C | | Boiling point | 307.2±52.0 °C(Predicted) | | density | 1.76±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -2.04±0.30(Predicted) | | Appearance | White to off-white Solid | | CAS DataBase Reference | 2273-93-0(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 22 | | HazardClass | IRRITANT |
| | 2,6-Dichloro-7-methylpurine Usage And Synthesis |
| Uses | 2,6-DICHLORO-7-METHYLPURINE is used in the preparation and discover of novel mTOR INHIBITORS. | | Synthesis | A reaction was carried out in acetonitrile (200 mL) in the presence of potassium carbonate (1.2 eq., 4.39 g) with 2,6-dichloropurine (5.0 g, 1.0 eq.) and iodomethane (1.1 eq., 1.81 mL). The reaction mixture was stirred at 20 °C for 70 hours. After completion of the reaction, the solvent was removed by rotary evaporator. The crude product was separated by column chromatography (eluent: dichloromethane/methanol, 90/10, v/v) to afford 2,6-dichloro-9-methyl-9H-purine (3.55 g, 66% yield) and 2,6-dichloro-7-methylpurine (1.61 g, 30% yield). | | References | [1] Patent: WO2005/28479, 2005, A2. Location in patent: Page/Page column 58
[2] Patent: US2011/86841, 2011, A1. Location in patent: Page/Page column 25
[3] Patent: WO2016/115434, 2016, A1. Location in patent: Page/Page column 222; 223
[4] Patent: WO2010/34707, 2010, A1. Location in patent: Page/Page column 15
[5] Patent: US2011/251217, 2011, A1. Location in patent: Page/Page column 6-7 |
| | 2,6-Dichloro-7-methylpurine Preparation Products And Raw materials |
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