2,6-Dichloro-7-methylpurine

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Products Intro: Product Name:2,6-Dichloro-7-methylpurine
CAS:2273-93-0
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
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Products Intro: Product Name:2,6-Dichloro-7-methylpurine
CAS:2273-93-0
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Products Intro: Product Name:2,6-Dichloro-7-methylpurine
CAS:2273-93-0
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-01368
2,6-Dichloro-7-methylpurine Basic information
Product Name:2,6-Dichloro-7-methylpurine
Synonyms:106282;2,6-Dichloro-7-methyl-7h-purine ,98%;2,6-DICHLORO-7-METHYLPURINE;2,6-DICHLORO-7-METHYL-7H-PURINE;7H-Purine, 2,6-dichloro-7-methyl-;2,6-dichloro-7-methyl-purin;2,6-DICHLORO-7-METHYLPURINE 97% (HPLC);2,6-DICHLORO-7-METHYLPURINE (2,6DCl7MeP)
CAS:2273-93-0
MF:C6H4Cl2N4
MW:203.03
EINECS:
Product Categories:
Mol File:2273-93-0.mol
2,6-Dichloro-7-methylpurine Structure
2,6-Dichloro-7-methylpurine Chemical Properties
Melting point 195.5-196 °C
Boiling point 307.2±52.0 °C(Predicted)
density 1.76±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka-2.04±0.30(Predicted)
AppearanceWhite to off-white Solid
CAS DataBase Reference2273-93-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 22
HazardClass IRRITANT
MSDS Information
2,6-Dichloro-7-methylpurine Usage And Synthesis
Uses2,6-DICHLORO-7-METHYLPURINE is used in the preparation and discover of novel mTOR INHIBITORS.
Synthesis
2,6-Dichloropurine

5451-40-1

Iodomethane

74-88-4

2,6-DICHLORO-9-METHYL-9H-PURINE

2382-10-7

2,6-Dichloro-7-methylpurine

2273-93-0

A reaction was carried out in acetonitrile (200 mL) in the presence of potassium carbonate (1.2 eq., 4.39 g) with 2,6-dichloropurine (5.0 g, 1.0 eq.) and iodomethane (1.1 eq., 1.81 mL). The reaction mixture was stirred at 20 °C for 70 hours. After completion of the reaction, the solvent was removed by rotary evaporator. The crude product was separated by column chromatography (eluent: dichloromethane/methanol, 90/10, v/v) to afford 2,6-dichloro-9-methyl-9H-purine (3.55 g, 66% yield) and 2,6-dichloro-7-methylpurine (1.61 g, 30% yield).

References[1] Patent: WO2005/28479, 2005, A2. Location in patent: Page/Page column 58
[2] Patent: US2011/86841, 2011, A1. Location in patent: Page/Page column 25
[3] Patent: WO2016/115434, 2016, A1. Location in patent: Page/Page column 222; 223
[4] Patent: WO2010/34707, 2010, A1. Location in patent: Page/Page column 15
[5] Patent: US2011/251217, 2011, A1. Location in patent: Page/Page column 6-7
Tag:2,6-Dichloro-7-methylpurine(2273-93-0) Related Product Information
Dichloromethylsilane 2,6-Dichloropurine 2-Chloro-5-chloromethylpyridine Methyl acrylate Methyl acetate Methylparaben Dichlorodimethylsilane Purine Bensulfuron methyl Dichloromethylphenylsilane Kresoxim-methyl Thiophanate-methyl 6-O-Methyl-guanine Methyl Parathion-methyl Methyl bromide 2-Chloropyrimidine 2-Chloropurine

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