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| | 3-hydroxy-1-methyl-4(1H)-Pyridinone Basic information |
| Product Name: | 3-hydroxy-1-methyl-4(1H)-Pyridinone | | Synonyms: | 3-hydroxy-1-methyl-4(1H)-Pyridinone;3-Hydroxy-1-Methylpyridin-4(1H)-one;4(1H)-Pyridinone, 3-hydroxy-1-methyl-;3-hydroxy-1-methylpyridin-4-one;Iron ketone impurity 12 (impurity F) | | CAS: | 50700-61-3 | | MF: | C6H7NO2 | | MW: | 125.13 | | EINECS: | | | Product Categories: | | | Mol File: | 50700-61-3.mol |  |
| | 3-hydroxy-1-methyl-4(1H)-Pyridinone Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | Appearance | Off-white to light brown Solid |
| | 3-hydroxy-1-methyl-4(1H)-Pyridinone Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 3-hydroxy-1-methyl-1H-pyridin-4-one from 1-methyl-3-benzyloxy-4(1H)-pyridinone was as follows: a mixture of 3-benzyloxy-1-methyl-1H-pyridin-4-one (14.1 g, 65.5 mmol) with 10% Pd/C (1.20 g) in methanol was placed in a Parr reactor at 50 psi The hydrogenation reaction was carried out under hydrogen pressure for 70 min. Upon completion of the reaction, the mixture was filtered through a Celite pad and the filtrate was concentrated to dryness. The residue was ground with acetone and the solid product was subsequently collected by filtration. After drying in a vacuum oven, 3-hydroxy-1-methyl-1H-pyridin-4-one was obtained as a light brown powder (7.13 g, 87% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.49 (br.s, 1H), 7.38 (s, 1H), 6.12 (br.s, 1H), 3.63 (s, 3H); MS-ESI (m/z): 125.7 [M + 1]+. | | References | [1] Patent: US2008/242706, 2008, A1. Location in patent: Page/Page column 28 |
| | 3-hydroxy-1-methyl-4(1H)-Pyridinone Preparation Products And Raw materials |
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