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| | 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Basic information |
| Product Name: | 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine | | Synonyms: | 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyrimidine, 2,4,5-trichloro-;EOS-60657;2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimid;2,4,5Trichloro7Hpyrrolo[2,3d]pyrimid,2,4,5 Trichloro 7H pyrrolo[2,3 d]pyrimid;cas no 1053228-28-6 for sale;cas no 1053228-28-6 price USD;cas no 1053228-28-6 | | CAS: | 1053228-28-6 | | MF: | C6H2Cl3N3 | | MW: | 222.46 | | EINECS: | 200-589-5 | | Product Categories: | pyrimidine;Heterocycle-Pyrimidine series | | Mol File: | 1053228-28-6.mol | ![2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Structure](CAS2/GIF/1053228-28-6.gif) |
| | 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties |
| Melting point | 225 °C(Solv: dichloromethane (75-09-2)) | | density | 1.791±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 8.69±0.50(Predicted) | | Appearance | White to off-white Solid |
| | 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Usage And Synthesis |
| Synthesis | 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (2.0 g, 10.64 mmol) was used as a starting material, which was dissolved in dichloromethane/tetrahydrofuran (DCM/THF, 15 mL/6 mL) mixed solvent. Subsequently, N-chlorosuccinimide (NCS, 1.70 g, 12.76 mmol) was added to the solution. The reaction mixture was placed in a microwave reactor, heated to 90 °C and kept at this temperature for 2.5 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by fast column chromatography with the eluent being a 9:1 (v/v) hexane/ethyl acetate solvent mixture to afford 2,4,5-trichloro-7H-pyrrolo[2,3-d]pyrimidine (2.2 g, 93% yield) as a white crystalline solid. Mass spectrometry (MS) analysis showed m/z 223.48 [M + 1]. | | References | [1] Chemistry - A European Journal, 2015, vol. 21, # 34, p. 11976 - 11979
[2] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 5, p. 584 - 589
[3] Patent: WO2016/130920, 2016, A2. Location in patent: Page/Page column 115
[4] Patent: WO2018/4306, 2018, A1. Location in patent: Page/Page column 127
[5] Organic Letters, 2016, vol. 18, # 9, p. 1976 - 1979 |
| | 2,4,5-Trichloro-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials |
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