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| | 2'-Bromo-4-chloro-biphenyl Basic information |
| Product Name: | 2'-Bromo-4-chloro-biphenyl | | Synonyms: | 1,1'-Biphenyl, 2-bromo-4'-chloro-;2-Bromo-4`-chloro-bipheny;1-bromo-2-(4-chlorophenyl)benzene;2-Bromo-4'-chloro-1'-biphenyl;2-bromo-2-(4-chlorophenyl)benzene;Boronic, B-(4'-chloro[1,1'-biphenyl]-2-yl)-;l-bromo-2-(4-chlorophenyl)benzene;2-Bromo-4’-chlorobiphenyl | | CAS: | 179526-95-5 | | MF: | C12H8BrCl | | MW: | 267.55 | | EINECS: | | | Product Categories: | | | Mol File: | 179526-95-5.mol |  |
| | 2'-Bromo-4-chloro-biphenyl Chemical Properties |
| Melting point | 41 °C | | Boiling point | 325.5±17.0 °C(Predicted) | | density | 1.463 | | storage temp. | Sealed in dry,Room Temperature | | form | powder to lump | | color | White to Orange to Green | | InChI | InChI=1S/C12H8BrCl/c13-12-4-2-1-3-11(12)9-5-7-10(14)8-6-9/h1-8H | | InChIKey | WSHZWUXRWQVZQP-UHFFFAOYSA-N | | SMILES | C1(C2=CC=C(Cl)C=C2)=CC=CC=C1Br |
| | 2'-Bromo-4-chloro-biphenyl Usage And Synthesis |
| Chemical Properties | off-white solid | | Synthesis | 1-Bromo-2-iodobenzene (30 g, 106 mmol) and 4-chlorophenylboronic acid (16.9 g, 108.6 mmol) were added to an aqueous 2M potassium carbonate solution (100 ml) in dioxane solution. Subsequently, tetrakis(triphenylphosphine)palladium (2.45 g, 2 mol%) was added as a catalyst. The reaction mixture was heated and reacted under stirring for 4 hours. After completion of the reaction, it was cooled to room temperature and the reaction was quenched with potassium carbonate solution followed by separation of the aqueous and organic layers. After the organic layer was concentrated under reduced pressure to remove the solvent, it was purified by column chromatography (eluent: hexane) to afford the target product 2-bromo-4'-chloro-1,1'-biphenyl (A1) as a white solid (25.3 g, 90% yield). | | References | [1] Patent: KR2017/41159, 2017, A. Location in patent: Paragraph 0274-0276
[2] Organic Letters, 2015, vol. 17, # 2, p. 386 - 389
[3] Organic Letters, 2013, vol. 15, # 24, p. 6186 - 6189
[4] Advanced Synthesis and Catalysis, 2018, vol. 360, # 16, p. 3049 - 3054
[5] Chemical Communications, 2014, vol. 50, # 17, p. 2193 - 2195 |
| | 2'-Bromo-4-chloro-biphenyl Preparation Products And Raw materials |
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