Amino-PEG2-acid

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Amino-PEG2-acid Suppliers list
Company Name: airuikechemical co., ltd.
Tel: +86-18353166132
Email: sales02@airuikechemical.com
Products Intro: Product Name:α-amine-ω-propionic acid diethylene glycol
CAS:791028-27-8
Purity:99.9% Package:1Kg;0.00;USD|5Kg;0.00;USD|25Kg;0.00;USD
Company Name: LAURENT
Tel: +8618100176782
Email: sun@laurentpeg.com
Products Intro: Product Name:NH2-PEG2-CH2CH2COOH
CAS:791028-27-8
Purity:98% Package:1g;|100g;|1000g;
Company Name: 9i LLC
Tel: +18039569191
Email: MWan@NiNeiLab.com
Products Intro: Product Name:α,ω-amine--propionic acid diethylene glycol
CAS:791028-27-8
Purity:min.98% Package:225USD/1 g Remarks:NA563
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070
Email: product@chemlin.com.cn
Products Intro: CAS:791028-27-8
Purity:98% Package:g-Kg Remarks:Yellow oil
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: CAS:791028-27-8
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G

Amino-PEG2-acid manufacturers

  • Amino-PEG2-COOH
  • Amino-PEG2-COOH pictures
  • 2025-06-07
  • CAS:791028-27-8
  • Min. Order: 250mg
  • Purity: >98.00%
  • Supply Ability: 250mg
Amino-PEG2-acid Basic information
Product Name:Amino-PEG2-acid
Synonyms:α-amine-ω-propionic acid diethylene glycol;alpha-aMine-oMega-propionic acid diethylene glycol;3-[2-(2-Aminoethoxy)ethoxy]-propanoic acid;Amino-PEG2-acid;Amino-PEG2-propionic acid;H2N-PEG2-CH2CH2COOH;AMINE-PEG2-COOH;Amino-PEG2-C2-acid
CAS:791028-27-8
MF:C7H15NO4
MW:177.2
EINECS:
Product Categories:PEG-COOtBu;ADCs Linkers;peg
Mol File:791028-27-8.mol
Amino-PEG2-acid Structure
Amino-PEG2-acid Chemical Properties
Boiling point 331.5±27.0 °C(Predicted)
density 1.142±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility soluble in water
pka4.27±0.10(Predicted)
form Solid
color White to off-white
Appearancewhite to off-yellow powder
InChIInChI=1S/C7H15NO4/c8-2-4-12-6-5-11-3-1-7(9)10/h1-6,8H2,(H,9,10)
InChIKeyDEZXLFKSYRODPB-UHFFFAOYSA-N
SMILESC(O)(=O)CCOCCOCCN
Safety Information
HS Code 2918999090
MSDS Information
Amino-PEG2-acid Usage And Synthesis
DescriptionAmino-PEG2-acid is a PEG reagent containing an amino group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
UsesAmino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG2-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biological ActivityAmino-PEG2-C2-acid is a cleavable 3-unit PEG ADClinker for the synthesis of antibody-drug conjugated Ck (ADC). It is also a PEG-based PROTAClinker that can be used for PROTAC synthesis.
in vivoADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
IC 50Cleavable Linker; PEGs
References[1] Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof. WO2016197946A1.
Amino-PEG2-acid Preparation Products And Raw materials
Raw materialsPropionic acid-->Polyethylene Glycol-->Ethylamine
Tag:Amino-PEG2-acid(791028-27-8) Related Product Information
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