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| | Farnesyl Pyrophosphate Triammonium Salt Basic information |
| Product Name: | Farnesyl Pyrophosphate Triammonium Salt | | Synonyms: | (E,E)-Diphosphoric Acid Mono(3,7,11-triMethyl-2,6,10-dodecatrienyl) Ester TriaMMoniuM Salt;Diphosphoric Acid P-[(2E,6E)-3,7,11-TriMethyl-2,6,10-dodecatrien-1-yl] Ester AMMoniuM Salt;Farnesyl Pyrophosphate Ammonium Salt, in Ethanol
DISCONTINUED. Please see F102470;Farensyl Pyrophosphate D3 Triammonium Salt;(E,E)-Farnesyl Pyrophosphate ammonium salt;Pasritamig | | CAS: | 116057-57-9 | | MF: | C15H37N3O7P2 | | MW: | 433.417702 | | EINECS: | | | Product Categories: | Aliphatics;Aliphatics, Phosphorylating and Phosphitylating Agents;Phosphorylating and Phosphitylating Agents | | Mol File: | 116057-57-9.mol |  |
| | Farnesyl Pyrophosphate Triammonium Salt Chemical Properties |
| storage temp. | Amber Vial, -20°C Freezer, Under Inert Atmosphere | | solubility | Methanol:NH4OH (70:30): * 1 mg/ml | | form | Solid | | color | White to Brown | | Stability: | Hygroscopic, Light Sensitive, Temperature Sensitive |
| | Farnesyl Pyrophosphate Triammonium Salt Usage And Synthesis |
| Description | Farnesyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway and used in the biosynthesis of terpenes, terpenoids, and sterols. It also serves as a donor in post-translational isoprenylation of proteins. FPP has been identified as an antagonist of P2Y12 receptors (IC50 = 45 μM), attenuating platelet aggregation. It has also been shown to regulate adipocyte function as an endogenous PPARγ agonist. Additionally, because of a flexible hydrocarbon chain that enables different conformations, FPP is a promiscuous ligand for a subset of nuclear receptors. | | Chemical Properties | Pale Yellow Low Melting Solid | | Uses | Isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular mass G proteins, including Ras. | | Uses | Isoprenoid from the intracellular mevalonate pathway, Farnesyl Pyrophosphate Triammonium Salt can be used for prenylation of several low molecular mass G proteins, including Ras. | | References | [1] MCTAGGART S J. Isoprenylated proteins.[J]. Cellular and Molecular Life Sciences, 2006, 63 3: 255-267. DOI: 10.1007/s00018-005-5298-6
[2] CARL HGBERG. Farnesyl pyrophosphate is an endogenous antagonist to ADP-stimulated P2Y receptor-mediated platelet aggregation.[J]. Thrombosis and haemostasis, 2012, 108 1: 119-132. DOI: 10.1160/th11-10-0749
[3] TSUYOSHI GOTO. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist.[J]. Biochemical Journal, 2011: 111-119. DOI: 10.1042/bj20101939
[4] RITU GOYANKA. Nuclear receptor engineering based on novel structure activity relationships revealed by farnesyl pyrophosphate.[J]. Protein Engineering Design & Selection, 2010, 23 11: 809-815. DOI: 10.1093/protein/gzq056 |
| | Farnesyl Pyrophosphate Triammonium Salt Preparation Products And Raw materials |
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