TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346
| 中文名称 | TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346 |
|---|---|
| 中文同义词 | 奥米加匹马来酸盐;马来酸CGP3466B;化合物:CGP 3466B maleate;化合物：CGP 3466B maleate |
| 英文名称 | N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)aminemaleate |
| 英文同义词 | CGP 3466B maleate;N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)aminemaleate;CGP 3466 (maleate);CGP3466B;CGP-3466B;TCH 346 maleate;TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346;CGP3466B maleate salt |
| CAS号 | 200189-97-5 |
| 分子式 | C23H21NO5 |
| 分子量 | 391.42 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 200189-97-5.mol |
| 结构式 |  |
TCH 346 MALEATE; CGP3466B; CGP-3466B; TCH346; TCH-346 性质
| 储存条件 | Store at +4°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 白色 |
| InChI | 1S/C19H17NO.C4H4O4/c1-3-12-20(2)14-16-13-15-8-4-6-10-18(15)21-19-11-7-5-9-17(16)19;5-3(6)1-2-4(7)8/h1,4-11,13H,12,14H2,2H3;1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChIKey | SQAZQLMBEHYFJA-BTJKTKAUSA-N |
| SMILES | N(CC1=Cc2c(cccc2)Oc3c1cccc3)(CC#C)C.OC(=O)\C=C/C(=O)O |
Omigapil maleate 是一种具有口服活性的 GAPDH 亚硝基化抑制剂，可消除 Aβ1-42 诱导的小鼠 tau 乙酰化，记忆障碍和运动功能障碍，Omigapil maleate 具有研究阿尔茨海默症的潜力。Omigapil maleate (CGP3446B maleate) 是一种有效的凋亡 (apoptosis) 抑制剂。Omigapil maleate 可用于研究先天性肌营养不良 (CMD)。
Apoptosis
Treatment of mice with Omigapil (0.1 mg/kg) results in improved muscle regeneration and increased force.
| Animal Model: | 12-week-old dyW/ mag mice |
| Dosage: | 0.1 mg/kg |
| Administration: |
For the first week of drug treatment, administered once daily by intraperitoneal injection.
After weaning (3 weeks of age), applied once daily by oral gavage. |
| Result: |
Reduced the muscle fibre loss.
Many of the functional parameters were significantly improved by omigapil. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |