N-DeMethyl Ivabradine Hydrochloride

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N-DeMethyl Ivabradine Hydrochloride manufacturers

  • Ivabradine Impurity
  • Ivabradine Impurity pictures
  • 2025-12-16
  • CAS:1246638-08-3
  • Min. Order: 10mg
  • Purity: 98%+
  • Supply Ability: 100000000
N-DeMethyl Ivabradine Hydrochloride Basic information
Product Name:N-DeMethyl Ivabradine Hydrochloride
Synonyms:N-DeMethyl Ivabradine Hydrochloride;3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]aMino]propyl]-1,3,4,5-tetrahydro-7,8-diMethoxy-3-benzazepin-2-one Hydrochloride;S 18982;N-DesMethyl Ivabradine Hydrochloride;Ivabradine metabolite N-Demethyl Ivabradine (hydrochloride);N-Desmethyl Ivabradine HCl;Ivabradine Impurity b;I-305
CAS:1246638-08-3
MF:C26H34N2O5.ClH
MW:491.02
EINECS:
Product Categories:Amines;Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:1246638-08-3.mol
N-DeMethyl Ivabradine Hydrochloride Structure
N-DeMethyl Ivabradine Hydrochloride Chemical Properties
Melting point 193-196°C
storage temp. Refrigerator
solubility DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
form A crystalline solid
color White to off-white
Major Applicationpharmaceutical small molecule
InChIKeyMIIIKWNQFDQJGS-OZYVVJTJNA-N
SMILESC([C@H]1CC2=CC(OC)=C(OC)C=C12)NCCCN1CCC2=CC(OC)=C(OC)C=C2CC1=O.Cl |&1:1,r|
Safety Information
WGK Germany WGK 3
Storage Class6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard ClassificationsAcute Tox. 4 Oral
Aquatic Chronic 2
Repr. 1B
STOT RE 2
MSDS Information
N-DeMethyl Ivabradine Hydrochloride Usage And Synthesis
DescriptionN-desmethyl Ivabradine is an active metabolite of ivabradine . Ivabradine is metabolized by the cytochrome P450 (CYP) isoform CYP3A4.
Chemical PropertiesBeige Solid
UsesIvabradine (I940500) metabolite.
References[1] GIAN MARCO ROSA. An evaluation of the pharmacokinetics and pharmacodynamics of ivabradine for the treatment of heart failure.[J]. Expert Opinion on Drug Metabolism & Toxicology, 2014, 10 2: 279-291. DOI: 10.1517/17425255.2014.876005
N-DeMethyl Ivabradine Hydrochloride Preparation Products And Raw materials
Tag:N-DeMethyl Ivabradine Hydrochloride(1246638-08-3) Related Product Information
ent-Ivabradine Hydrochloride Ivabradine Impurity 1 Hydrochloride INDEX NAME NOT YET ASSIGNED 3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)-N-(((S)-3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N-methylpropan-1-amine oxide 3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3-dihydro-7,8-diMethoxy-H-3-benzazepin-2-one 7-DeMethyl Ivabradine 7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-one 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one) (3,4-Dimethoxyphenyl)acetic acid Hydroxy Ivabradine N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide 8-DeMethyl Ivabradine 3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one) (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride 4,5-Dimethoxy-1-cyanobenzocyclobutane C-(3,4-Dimethoxy-bicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)-methylamine