- FH535
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- $32.00 / 5mg
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2026-05-27
- CAS:108409-83-2
- Min. Order:
- Purity: 98.25%
- Supply Ability: 10g
- FH535
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- $0.00 / 1bottle
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2024-11-01
- CAS:108409-83-2
- Min. Order: 1bottle
- Purity: 98%
- Supply Ability: 100bottles
- FH 535
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- $9.80 / 1.79999995231628KG
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2020-01-09
- CAS:108409-83-2
- Min. Order: 1g
- Purity: ≥99%
- Supply Ability: 100kg
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| | FH 535 Chemical Properties |
| Melting point | 141-142℃ | | Boiling point | 526.3±60.0 °C(Predicted) | | density | 1.566±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble20mg/mL | | form | Yellow solid | | pka | 5.83±0.10(Predicted) | | color | Tan | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. | | InChI | 1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3 | | InChIKey | AXNUEXXEQGQWPA-UHFFFAOYSA-N | | SMILES | Cc1cc(ccc1NS(=O)(=O)c2cc(Cl)ccc2Cl)[N+]([O-])=O |
| Hazard Codes | Xi | | Risk Statements | 41 | | Safety Statements | 36 | | WGK Germany | 3 | | HS Code | 29350090 | | Storage Class | 11 - Combustible Solids |
| | FH 535 Usage And Synthesis |
| Description | FH-535 (108409-83-2) suppresses Wnt/β-catenin signaling. It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1 but not the corepressors NCoR and SMRT.1Inhibits the migration and growth of breast cancer cell lines2 as well as colon, lung and liver cell lines1. FH-535 is a useful tool for probing the involvement of Wnt signaling pathway.3,4 | | Chemical Properties | Dark Yellow Solid | | Uses | A cell-permeable compound that inhibits Wnt/β-catenin and PPAR | | Uses | Antagonizes Wnt/β-catenin/Tcf-mediated transcription as well as PPARγ and δ activity. Able to inhibit the recruitment of the co-activators β-catenin and GRIP1, both of which are activators for both pathways. | | Definition | ChEBI: 2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide is a sulfonamide. | | Biochem/physiol Actions | FH535 has the ability to block the development of colon cancer cells. It can change several cancer-associated biological processes. FH535 can also prevent PARylation of Axin2 in osteosarcoma cells. | | storage | +4°C | | References | [1] SHLOMO HANDELI Julian A S. A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities.[J]. Molecular Cancer Therapeutics, 2008, 7 3: 521-529. DOI:10.1158/1535-7163.mct-07-2063
[2] JOJI IIDA. FH535 inhibited migration and growth of breast cancer cells.[J]. PLoS ONE, 2012: e44418. DOI:10.1371/journal.pone.0044418
[3] KATHRYN A FREWER. A role for WISP2 in colorectal cancer cell invasion and motility.[J]. Cancer Genomics & Proteomics, 2013, 10 4: 187-196.
[4] POLK W W. FH535 potentiation of cigarette smoke condensate cytotoxicity is associated with changes in β-catenin and EGR-1 signaling.[J]. International Journal of Toxicology, 2012, 31 4: 380-389. DOI:10.1177/1091581812447956
[5] TSUYOSHI MORITA Ken’ichiro H. Tumor Progression Is Mediated by Thymosin-β4 through a TGFβ/MRTF Signaling Axis.[J]. Molecular Cancer Research, 2018, 16 5: 880-893. DOI:10.1158/1541-7786.mcr-17-0715 |
| | FH 535 Preparation Products And Raw materials |
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