ARRY-380

ARRY-380 Suppliers list

Company Name:	ATK CHEMICAL COMPANY LIMITED
Tel:	+undefined-21-51877795
Email:	ivan@atkchemical.com
Products Intro:	Product Name:Arry-830 CAS:937265-83-3 Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G

Company Name:	Hubei xin bonus chemical co. LTD
Tel:	86-13657291602
Email:	linda@hubeijusheng.com
Products Intro:	Product Name:ARRY-380 CAS:937265-83-3 Purity:0.99 Package:5KG;1KG

Company Name:	TargetMol Chemicals Inc.
Tel:	+17819995354
Email:	marketing@targetmol.com
Products Intro:	Product Name:ARRY-380 (analog ) CAS:937265-83-3 Purity:98.22% Package:1mg;30USD\|2mg;42USD\|5mg;68USD Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	Dideu Industries Group Limited
Tel:	+86-29-89586680 +86-15129568250
Email:	1026@dideu.com
Products Intro:	Product Name:ARRY-380 CAS:937265-83-3 Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer

Company Name:	Zhejiang J&C Biological Technology Co.,Limited
Tel:	+1-2135480471 +1-2135480471
Email:	sales@sarms4muscle.com
Products Intro:	Product Name:ARRY-380 CAS:937265-83-3 Purity:99% Package:5KG;1KG Remarks:ARRY-380

ARRY-380 manufacturers

ARRY-380 Basic information

Product Name:	ARRY-380
Synonyms:	ARRY-380 (analog );Arry-830;ARRY-380;ARRY380; ARRY 380;6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a];Arry-380, >=98%;ARRY-380;6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine;HER2-Inhibitor-1
CAS:	937265-83-3
MF:	C29H27N7O4S
MW:	569.63
EINECS:	813-083-0
Product Categories:	Inhibitors;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:	937265-83-3.mol

ARRY-380 Chemical Properties

density	1.43
storage temp.	Store at -20°C
solubility	≥28.5 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form	solid
pka	6.34±0.19(Predicted)
color	Light brown to brown

Safety Information

MSDS Information

ARRY-380 Usage And Synthesis

Description	Arry-380 analog was designed as an inhibitor of EGFR (ErbB1).
Uses	ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM and also inhibits EGFR with IC50 of 4 μM.
Uses	Labelled ARRY-380. ARRY-380 is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2.
target	p95-HER2
references	[1] s. l. moulder, v. borges, s. k. l. chia, t. baetz, e. barrett, j. garrus, k. guthrie, c. kass, e. laird, j. lyssikatos, f. marmsater, e. wallace. arry-380, a selective her2 inhibitor: from drug design to clinical evaluation. poster of aacr-nci-eortc, nov 12-16, 2011, san francisco, ca. [2] victoria dinkel, deborah anderson, shannon winski, jim winkler, kevin koch and patrice lee. arry-380, a potent, small molecule inhibitor of erbb2, increases survival in intracranial erbb2+ xenograft models in mice. poster available at www.arraybiopharma.com [3] s. chia, t. baetz, s. d'aloisio, g. fernetich, b. freeman, e. barrett, c. kass, j. kang, b. sajan, s. moulder, and j. garrus. a phase 1 study to assess the safety, tolerability and pharmacokinetics of arry-380 – an oral inhibitor of her2. cancer res 2009;69(24 suppl):abstract nr 5111.

ARRY-380 Preparation Products And Raw materials

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