|
|
| | 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid Basic information |
| Product Name: | 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid | | Synonyms: | 4-Amino-5-chloro-2,3-dihydro-7-benzofurancarboxylic acid;4-Amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid;4-aMino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid;4-AMino-5-chloro-2,3-dihydro-7-benzofurane karboxylic acid;4-amino-5-chloro-2,3-dihydro-1-benzofuran-7-carboxylic acid;Prucalopride Impurity A;Prucalopride int;4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic Acid > | | CAS: | 123654-26-2 | | MF: | C9H8ClNO3 | | MW: | 213.62 | | EINECS: | 1592732-453-0 | | Product Categories: | | | Mol File: | 123654-26-2.mol |  |
| | 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid Chemical Properties |
| Melting point | 242 °C(dec.) | | Boiling point | 406.5±45.0 °C(Predicted) | | density | 1.566 | | storage temp. | 2-8°C(protect from light) | | solubility | DMSO (Slightly), Methanol (Slightly, Heated) | | form | Solid | | pka | 4.45±0.20(Predicted) | | color | Light Brown | | InChI | InChI=1S/C9H8ClNO3/c10-6-3-5(9(12)13)8-4(7(6)11)1-2-14-8/h3H,1-2,11H2,(H,12,13) | | InChIKey | KRMUVKSAOVLXLF-UHFFFAOYSA-N | | SMILES | O1C2=C(C(O)=O)C=C(Cl)C(N)=C2CC1 |
| | 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid Usage And Synthesis |
| Uses | 4-Amino-5-chloro-2,3-dihydro-7-benzofurancarboxylic Acid, can be used as an intermediate for the synthesis of Prucalopride (P838950), a selective 5-HT4 receptor agonist used effective for chronic constipation. | | Synthesis | Firstly, adding methyl 4-(acetyl amino)-2-hydroxy-3-(2-hydroxy ethyl) benzoate into an organic solvent, adding triphenylphosphine and azo dioctyl phthalate diethyl ester, performing cyclization to obtain a methyl 4-acetamido-2,3-dihydro benzofuran-7-formate rough product, directly chloridizing the rough product by using N-chloro succinimide to obtain a rough product methyl 4-acetamide amino-5-chloro-7-benzofuran formate, and performing hydrolysis and purification to obtain a 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid pure product. |
| | 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid Preparation Products And Raw materials |
|