- Sodium D-pantothenate
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- $0.00 / 1Kg/Bag
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2026-03-09
- CAS:867-81-2
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 500kg
- Sodium D-pantothenate
-
- $0.00 / 1kg
-
2026-03-09
- CAS:867-81-2
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100KG
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| Product Name: | Sodium D-pantothenate | | Synonyms: | (r)-n-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-beta-alanine monosodium salt;SODIUM D-PANTOTHENATE;SODIUM PANTHOTENATE;SODIUM PANTOTHENATE;beta-alanine,n-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,monosodiumsalt,(t;heta)-;monosodiumsalt,d-pantothenicaci;N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,monosodiumsalt,(R)-.beta.-Alanine | | CAS: | 867-81-2 | | MF: | C9H16NNaO5 | | MW: | 241.22 | | EINECS: | 212-768-6 | | Product Categories: | API;Biochemistry;Vitamins;Vitamins and derivatives;OLED | | Mol File: | 867-81-2.mol |  |
| | Sodium D-pantothenate Chemical Properties |
| Melting point | 171-178 °C(lit.) | | alpha | D25 +27.1° (c = 2) | | refractive index | 27 ° (C=5, H2O) | | storage temp. | Inert atmosphere,2-8°C | | solubility | Water (Slightly) | | form | Solid | | color | White to Off-White | | Optical Rotation | 24.2°(C=0.01g/mI, H2O, 20°C, 589nm) | | Stability: | Hygroscopic | | Cosmetics Ingredients Functions | HAIR CONDITIONING | | InChI | InChI=1/C9H17NO5.Na/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;+1/p-1/t7-;/s3 | | InChIKey | GQTHJBOWLPZUOI-WMASNCOMNA-M | | SMILES | [C@H](O)(C(=O)NCCC([O-])=O)C(C)(C)CO.[Na+] |&1:0,r| | | LogP | -0.849 (est) | | CAS DataBase Reference | 867-81-2(CAS DataBase Reference) | | EPA Substance Registry System | .beta.-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-, monosodium salt (867-81-2) |
| | Sodium D-pantothenate Usage And Synthesis |
| Description | Sodium D-pantothenate is the sodium salt of the biological active
enantiomer of pantothenic acid (vitamin B5). As D-pantothenic acid
is a precursor in the biosynthesis of coenzyme A, sodium D-
pantothenate is used in the synthesis of coenzyme A. It is also used
in foods as a dietary supplement. | | References | [1] George A. Burdock, Encyclopedia of Food and Color Additives,
volume 3, 1996 | | Chemical Properties | White crystal or powder | | Uses | D-Pantothenic acid sodium (Sodium pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid sodium plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism[1]. | | Synthesis | The general procedure for the synthesis of sodium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propionate from sodium 3-aminopropionate and dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone was as follows: 55.5 g of sodium 3-aminopropionate and 65 g of dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone were dissolved in 350 ml of anhydrous ethanol and heated to reflux for 3 hours. After completion of the reaction, the reaction mixture was filtered while hot and the reaction vessel was washed with 50 ml of ethanol. The washed solution was combined with the filtrate and the combined filtrate was allowed to stand at 0 °C for 5 days. Subsequently, it was filtered and the resulting solid was washed with a small amount of ethanol. Finally, the solid was dried to constant weight under reduced pressure at room temperature to obtain 76.3 g of white crystalline powder, namely sodium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propionate (sodium D-pantothenate), whose crystal structure is as described in GB565976. | | in vivo | Pantothenic acid (PTA; 3x10, 3x100, and 3x300 mg/kg) decreases Valproic acid (VPA; 300, 400, and 500 mg/kg, s.c.)-induced neural tube defects in mice[2]. | Animal Model: | Female ICR mice weighing 29-35 g[2] | | Dosage: | 3x10, 3x100, and 3x300 mg/kg (10 mL/kg, volume administered) | | Administration: | Injected intraperitoneally (i.p.) on day 8.5 of gestation | | Result: | Significantly reduced VPA (300, 400, and 500 mg/kg, s.c.)-induced exencephaly, while none of the other external malformations such as open eyelid or skeletal malformations such as fused, absent, or bifurcated ribs and fused thoracic vertebrae and fused sternebrae were reduced. |
| | IC 50 | Human Endogenous Metabolite | | Purification Methods | Crystallise the salt from absolute EtOH. It is very hygroscopic (keep in sealed ampoules). The free acid is a viscous hygroscopic oil with [] 25D +37.5o (c 5, H2O), easily destroyed by acids and bases. [Beilstein 4 IV 2569.] | | References | [1] Shuai Chen, et al. Metabolomic analysis of the toxic effect of chronic exposure of cadmium on rat urine. Environ Sci Pollut Res Int. 2018 Feb;25(4):3765-3774. DOI:10.1007/s11356-017-0774-8
[2] M Sato, et al. Pantothenic acid decreases valproic acid-induced neural tube defects in mice (I). Teratology. 1995 Sep;52(3):143-8. DOI:10.1002/tera.1420520306 |
| | Sodium D-pantothenate Preparation Products And Raw materials |
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