|
|
| | 3-Oxa-9-azabicyclo[3.3.1]nonan-7-one Hydrochloride Basic information |
| | 3-Oxa-9-azabicyclo[3.3.1]nonan-7-one Hydrochloride Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | Appearance | white solid |
| | 3-Oxa-9-azabicyclo[3.3.1]nonan-7-one Hydrochloride Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 3-oxa-9-azabicyclo[3.3.1]nonan-7-one hydrochloride from 9-Boc-7-oxa-9-azabicyclo[3.3.1]nonan-3-one was as follows: tert-butyl 7-oxo-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate A3 (160 mg, 0.66 mmol) was dissolved in Et2O ( 3 M solution, 3 mL) in HCl was added.The reaction mixture was stirred at room temperature for 2-3 hrs. After completion of the reaction, the mixture was concentrated and the crude product obtained was washed with ether to give the target product 3-oxa-9-azabicyclo[3.3.1]nonan-7-one hydrochloride as a yellow solid (120 mg, 100% yield).LCMS analysis results: retention time (RT) 0.24 min, m/z 142.1 [M + H]+. | | References | [1] Patent: WO2017/153519, 2017, A1. Location in patent: Page/Page column 65; 66 |
| | 3-Oxa-9-azabicyclo[3.3.1]nonan-7-one Hydrochloride Preparation Products And Raw materials |
|