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| | 16(R)-AFP 07 (free acid) Basic information |
| Product Name: | 16(R)-AFP 07 (free acid) | | Synonyms: | 16(R)-AFP 07 (free acid);PVHIRYQSPDZLLG-HWMGRDFZSA-N;16(R)-AFP 07;(5Z)-5-[(3aR,4R,5R,6aS)-3,3-difluoro-5-hydroxy-4-[(E,3R,4S)-3-hydroxy-4-methylnon-1-en-6-ynyl]-4,5,6,6a-tetrahydro-3aH-cyclopenta[b]furan-2-ylidene]pentanoic acid;Pentanoic acid, 5-[(3aR,4R,5R,6aS)-3,3-difluorohexahydro-5-hydroxy-4-[(1E,3R,4S)-3-hydroxy-4-methyl-1-nonen-6-ynyl]-2H-cyclopenta[b]furan-2-ylidene]-, (5Z)- (9CI) | | CAS: | 773825-80-2 | | MF: | C22H30F2O5 | | MW: | 412.47 | | EINECS: | | | Product Categories: | | | Mol File: | 773825-80-2.mol |  |
| | 16(R)-AFP 07 (free acid) Chemical Properties |
| Boiling point | 557.8±50.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | solubility | DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 1 mg/ml | | pka | 4.70±0.10(Predicted) |
| | 16(R)-AFP 07 (free acid) Usage And Synthesis |
| Description | Prostaglandin I2 is an unstable prostanoid which, through the ‘I prostanoid’ (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki = 0.561 nM).1 AFP 07 shows weaker affinity for EP receptors, with Ki values > 100 nM for EP1-3 and > 10 nM for EP4.1,2 16(R)-AFP 07 is an epimer of AFP 07. Its biological properties, particularly through the IP and EP receptors, remain to be evaluated. | | Uses | Prostaglandin I2 is an unstable prostanoid which, through the ‘I prostanoid’ (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki=0.561 nM).1 AFP 07 shows weaker affinity for EP receptors, with Ki values > 100 nM for EP1-3 and > 10 nM for EP4. 16(R)-AFP 07 is an epimer of AFP 07. Its biological properties, particularly through the IP and EP receptors, remain to be evaluated. | | References | 1. Chang, C.s., Negishi, M., Nakano, T., et al. 7,7-Difluoroprostacyclin derivative, AFP-07, a highly selective and potent agonist for the prostacyclin receptor Prostaglandins 53(2),83-90(1997).
2. Jones, R.L., and Chan, K. Distinction between relaxations induced via prostanoid EP4 and IP1 receptors in pig and rabbit blood vessels Br. J. Pharmacol. 134(2),313-324(2001). |
| | 16(R)-AFP 07 (free acid) Preparation Products And Raw materials |
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