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Product Name:3-Bromo-5-phenyl salicylic acid
CAS:4906-68-7
Purity:>=95% Remarks:Reach out to us for more information about custom solutions.
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3-bromo-5-phenyl Salicylic Acid manufacturers
- AKR1C1-IN-1
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- $89.00 / 5mg
-
2026-04-22
- CAS:4906-68-7
- Min. Order:
- Purity: 99.44%
- Supply Ability: 10g
- AKR1C1-IN-1
-
- $89.00 / 5mg
-
2026-04-22
- CAS:4906-68-7
- Min. Order:
- Purity: 99.44%
- Supply Ability: 10g
|
| | 3-bromo-5-phenyl Salicylic Acid Basic information |
| Product Name: | 3-bromo-5-phenyl Salicylic Acid | | Synonyms: | 3-bromo-5-phenyl Salicylic Acid;3-bromo-5-phenyl Salicylic Acid Exclusive;XVZSXNULHSIRCQ-UHFFFAOYSA-N;AKR1C1-IN-1;[1,1'-Biphenyl]-3-carboxylic acid, 5-bromo-4-hydroxy-;5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid;NSC-109116;3-bromo-5-phenylsalicyclic acid | | CAS: | 4906-68-7 | | MF: | C13H9BrO3 | | MW: | 293.11 | | EINECS: | 225-535-9 | | Product Categories: | | | Mol File: | 4906-68-7.mol |  |
| | 3-bromo-5-phenyl Salicylic Acid Chemical Properties |
| Melting point | 212-214 °C | | Boiling point | 401.2±45.0 °C(Predicted) | | density | 1.611±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMF: 15 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 0.1 mg/ml | | form | A crystalline solid | | pka | 2.45±0.14(Predicted) | | color | White to pink | | InChI | 1S/C13H9BrO3/c14-11-7-9(8-4-2-1-3-5-8)6-10(12(11)15)13(16)17/h1-7,15H,(H,16,17) | | InChIKey | XVZSXNULHSIRCQ-UHFFFAOYSA-N | | SMILES | OC1=C(C(O)=O)C=C(C2=CC=CC=C2)C=C1Br |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 3-bromo-5-phenyl Salicylic Acid Usage And Synthesis |
| Description | The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases, with AKR1C1 being a 20α-HSD and the other three being 3α-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20α-hydroxy progesterone. In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function. 3-bromo-5-phenyl Salicylic acid selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2 (Ki = 87 nM), AKR1C3 (Ki = 4.2 μM), and AKR1C4 (Ki = 18.2 μM). Moreover, it potently inhibits the metabolism of progesterone by bovine aortic endothelial cells overexpressing AKR1C1 (IC50 = 460 nM). | | Uses | AKR1C1-IN-1 is a potent and selective inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), with a Ki value of 4 nM for AKR1C1[1]. | | References | [1] El-Kabbani O, et al. Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1). J Med Chem. 2009 May 28;52(10):3259-64. DOI:10.1021/jm9001633 |
| | 3-bromo-5-phenyl Salicylic Acid Preparation Products And Raw materials |
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