CAY10574
| 中文名称 | CAY10574 |
|---|---|
| 中文同义词 | 化合物CAN508;4-((3,5-二氨基-1H-吡唑-4-基)偶氮基)苯酚;CAY10574,CDK9 KINASE抑制剂;化合物CAN508,10 MM DMSO 溶液;CAN508 ,E2373;CAN508 试剂;CAN508 试剂 |
| 英文名称 | CAY10574 |
| 英文同义词 | CAY10574;Cdk9 Inhibitor II;4-[2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]phenol;CAN-508 (CAN508);CaMKII Inhibitor, CK59 - CAS 140651-18-9 - Calbiochem;inhibit,CAN 508,ATP-competitive,Cyclin dependent kinase,esophageal,cells,CDK,CAN508,Inhibitor,adenocarcinoma,HT-29,CAN-508;Phenol, 4-[2-(3,5-diamino-1H-pyrazol-4-yl)diazenyl]-;4-((3,5-Diamino-1H-pyrazol-4-yl)diazenyl)phenol |
| CAS号 | 140651-18-9 |
| 分子式 | C9H10N6O |
| 分子量 | 218.22 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 140651-18-9.mol |
| 结构式 |  |
CAY10574 性质
| 沸点 | 638.3±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.67±0.1 g/cm3(Predicted) |
| 储存条件 | +2C to +8C |
| 溶解度 | DMF：0.5mg/mL；二甲基亚砜：0.5mg/mL |
| 酸度系数(pKa) | 8.52±0.30(Predicted) |
| 形态 | 黄色半固体 |
| 颜色 | 浅黄至黄色 |
| InChI | 1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15) |
| InChIKey | AYZRKFOEZQBUEA-UHFFFAOYSA-N |
| SMILES | [nH]1nc(c(c1N)N=Nc2ccc(cc2)O)N |
|
CDK9/cyclinT1 0.35 μM (IC 50 ) |
CDK2/cyclinE 20 μM (IC 50 ) |
cdk2/cyclin A 69 μM (IC 50 ) |
Cdk4/cyclin D1 13.5 μM (IC 50 ) |
CDK7/cyclin H 26 μM (IC 50 ) |
Cdk1/cyclin B 44 μM (IC 50 ) |
CAN508 reduces the frequency of S-phase cells of the cancer cell line HT-29 in antiproliferation assays.
CAN508 (20-40 μM; 72 hours) significantly reduces cell proliferation in a dose dependent manner in all three esophageal adenocarcinoma cell lines (SKGT4, OE33 and FLO-1 cells) with IC
50
s ranging from 34.99 to 91.09 μM.
CAN508 (40 μM; 72 hours) increases apoptosis in all three esophageal adenocarcinoma cells.
Apoptosis Analysis
| Cell Line: | SKGT4, OE33 and FLO-1 cells |
| Concentration: | 40 μM |
| Incubation Time: | 72 hours |
| Result: | Increased apoptosis by 2 fold in all three esophageal adenocarcinoma cells compared to untreated controls. |
CAN508 (60 mg/kg; i.p.; daily for 10 days) has antitumor effects in esophageal adenocarcinoma xenografts.
| Animal Model: | 4 weeks-old female nude mice (esophageal adenocarcinoma xenografts) |
| Dosage: | 60 mg/kg |
| Administration: | I.p.; daily for 10 days |
| Result: | Caused reduction of tumor growth starting from post-treatment day three with 50.83% reduction. |
安全信息
| WGK Germany | WGK 2 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-100429 | CAN508 | 140651-18-9 | 1 mg | 132元 |
| 2026/06/05 | HY-100429 | CAY10574 CAN508 | 140651-18-9 | 5mg | 261元 |