3-broMo-4H,5H-thieno[3,2-c]pyridin-4-one manufacturers
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| | 3-broMo-4H,5H-thieno[3,2-c]pyridin-4-one Basic information |
| Product Name: | 3-broMo-4H,5H-thieno[3,2-c]pyridin-4-one | | Synonyms: | 3-broMo-4H,5H-thieno[3,2-c]pyridin-4-one;3-BroMothieno[3,2-c]pyridin-4(5H)-one;3-broMo-4-hydroxy-[3,2-c]-thienopyridine;3-BROMO-4-HYDROXYTHIENO[3,2-C]PYRIDINE;3-Bromothieno[3,2-c]pyridin-4-ol;3-Bromothieno[3,2-c]pyridin-4(5H);Thieno[3,2-c]pyridin-4(5H)-one, 3-bromo-;3-Bromo-5H-thieno[3,2-c]pyridine-4-one | | CAS: | 799293-83-7 | | MF: | C7H4BrNOS | | MW: | 230.08 | | EINECS: | | | Product Categories: | | | Mol File: | 799293-83-7.mol | ![3-broMo-4H,5H-thieno[3,2-c]pyridin-4-one Structure](CAS/GIF/799293-83-7.gif) |
| | 3-broMo-4H,5H-thieno[3,2-c]pyridin-4-one Chemical Properties |
| Melting point | 273-278°C | | Boiling point | 468.6±45.0 °C(Predicted) | | density | 1.801±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 12.09±0.20(Predicted) | | form | solid | | Appearance | Light yellow to brown Solid | | InChI | 1S/C7H4BrNOS/c8-4-3-11-5-1-2-9-7(10)6(4)5/h1-3H,(H,9,10) | | InChIKey | AMWQWPCIUPRUFH-UHFFFAOYSA-N |
| Hazard Codes | T,C | | Risk Statements | 25-34-36 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 3260 8 / PGIII | | WGK Germany | 3 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Eye Dam. 1
Skin Corr. 1B |
| | 3-broMo-4H,5H-thieno[3,2-c]pyridin-4-one Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 3-bromo-4-hydroxythienopyridine from the compound (CAS: 799293-81-5) is as follows: 100 mL of diphenyl ether was heated to 210 °C under nitrogen protection, followed by the slow addition of a solution of (E)-3-(4-bromothiophene-2-yl)acryloyl azide (9.95 g, 386 mmol) dissolved in 50 mL of diphenyl ether. The reaction mixture was maintained at 210 °C for 15 min. After completion of the reaction, it was cooled to room temperature and diluted with 100 mL of cyclohexane. The precipitate was collected by filtration and dried under vacuum to give 6.6 g (yield: 74.4%) of the target product 3-bromo-4-hydroxythienopyridine as a brown solid. | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 5, p. 1167 - 1171
[2] Patent: US2013/116233, 2013, A1. Location in patent: Paragraph 1153
[3] Patent: US2007/161672, 2007, A1. Location in patent: Page/Page column 8
[4] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 1, p. 250 - 254
[5] Patent: WO2004/100947, 2004, A2. Location in patent: Page 26-27; 17 |
| | 3-broMo-4H,5H-thieno[3,2-c]pyridin-4-one Preparation Products And Raw materials |
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