4-c]pyridine manufacturers
- 4-c]pyridine
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![4-c]pyridine pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/538f6a6a-3e00-4c1f-8ed8-9bbf28e2ca68.jpg)
- $1.00
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2020-01-15
- CAS:1357947-08-0
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 200kg
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| | 4-c]pyridine Basic information |
| Product Name: | 4-c]pyridine | | Synonyms: | 1H-Pyrazolo[3,4-c]pyridine, 5-bromo-3-iodo-;5-broMo-3-iodo-1H-pyrazolo[3,4-c]pyridine | | CAS: | 1357947-08-0 | | MF: | C6H3BrIN3 | | MW: | 323.92 | | EINECS: | | | Product Categories: | | | Mol File: | 1357947-08-0.mol | ![4-c]pyridine Structure](CAS/20150408/GIF/1357947-08-0.gif) |
| | 4-c]pyridine Chemical Properties |
| Boiling point | 458.7±40.0 °C(Predicted) | | density | 2.559±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | solid | | pka | 7.72±0.40(Predicted) | | Appearance | Off-white to light yellow Solid |
| Hazard Codes | Xn | | Risk Statements | 22 |
| | 4-c]pyridine Usage And Synthesis |
| Synthesis | Step I. Preparation of 5-bromo-1H-pyrazolo[3,4-c]pyridine
To a solution of 6-bromo-4-methylpyridin-3-amine (7.76 g, 0.0415 mol) in acetic acid (412.8 mL, 7.260 mol) was added 4.0 ml of a 4.0 ml aqueous solution of sodium nitrite (2.87 g, 0.0416 mol) (Bioorg. Med. Chem. 15 (2007) 2441- 2452). The reaction mixture was stirred for 15 min and allowed to stand at room temperature (rt) for 2 days (d). The reaction mixture was concentrated and diluted with EtOAc and then washed with NaHCO3 and brine. The organic layer was dried over Na2SO4, filtered and concentrated. The crude was purified by chromatography (DCM/ MeOH, eluting with 5% MeOH) to afford 5-bromo-1H-pyrazolo[3,4-c]pyridine (79.1% yield).
Step II. Preparation of 5-bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine
A solution containing 5-bromo-1H-pyrazolo[3,4-c]pyridine (168.0 g, 848.4 mmol) and NIS (286.3 g, 1.27 mol) in DMF (1.2 L) was stirred at room temperature. The reaction mixture was poured into water then filtered. The solid was washed with water and 5% Na2S2O5. The crude product was dried under high vacuum overnight to give 5-bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine.
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| | 4-c]pyridine Preparation Products And Raw materials |
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