((2R,4S,5R)-4-(tert-butyldiphenylsilyloxy)-5-(hydroxyMethyl)-tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione
| 中文名称 | ((2R,4S,5R)-4-(tert-butyldiphenylsilyloxy)-5-(hydroxyMethyl)-tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione |
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| 中文同义词 | 化合物 3'-O-(T-BUTYLDIPHENYLSILYL)THYMIDINE;3'-(O)-叔丁基二苯基硅基胸苷 |
| 英文名称 | ((2R,4S,5R)-4-(tert-butyldiphenylsilyloxy)-5-(hydroxyMethyl)-tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione |
| 英文同义词 | ((2R,4S,5R)-4-(tert-butyldiphenylsilyloxy)-5-(hydroxyMethyl)-tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione;3-[(2R,4S,5R)-4-[tert-butyl(diphenyl)silyl]oxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione;3'-O-(t-Butyldiphenylsilyl)thymidine;3’-O-tert-Butyldiphenylsilylthymidine;2'-Deoxy-3'-O-[(2-methyl-2-propanyl)(diphenyl)silyl]-3,4-dihydrot hymidine;Thymidine, 3'-O-[(1,1-dimethylethyl)diphenylsilyl]-;3’-O-(t-Butyldiphenylsilyl)thymidine;1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione |
| CAS号 | 83467-48-5 |
| 分子式 | C26H32N2O5Si |
| 分子量 | 480.63 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 83467-48-5.mol |
| 结构式 |  |
((2R,4S,5R)-4-(tert-butyldiphenylsilyloxy)-5-(hydroxyMethyl)-tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione 性质
| 熔点 | 68-72 °C |
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| 密度 | 1.23±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 9.55±0.10(Predicted) |
((2R,4S,5R)-4-(tert-butyldiphenylsilyloxy)-5-(hydroxyMethyl)-tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione 用途与合成方法
3’-O-(t-Butyldiphenylsilyl) thymidine 是一种嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性，靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制 DNA 合成，诱导细胞凋亡 (apoptosis) 等。