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DMAPT manufacturers
- DMAPT
-
-
2026-05-26
- CAS:870677-05-7
- Purity: 99.91%
- Supply Ability: 10g
- DMAPT
-
-
2026-05-26
- CAS:870677-05-7
- Purity: 99.91%
- Supply Ability: 10g
|
| Product Name: | DMAPT | | Synonyms: | (1S,2R,4R,7~{Z},11S,12S)-12-[(dimethylamino)methyl]-4,8-dimethyl-3,14-dioxatricyclo[9.3.0.0^{2,4}]tetradec-7-en-13-one;DMAPT;UJNSFDHVIBGEJZ-KVUCBBCISA-N;Dimethylamino Parthenolide;Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 8-[(dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-, (1aR,4E,7aS,8S,10aS,10bR)-;NF-κB,Inhibitor,Nuclear factor-κB,inhibit,DMAPT,Nuclear factor-kappaB;DMAPT, NF-kappaB inhibitor;DMAPT, 10 mM in DMSO | | CAS: | 870677-05-7 | | MF: | C17H27NO3 | | MW: | 293.4 | | EINECS: | | | Product Categories: | | | Mol File: | 870677-05-7.mol |  |
| | DMAPT Chemical Properties |
| storage temp. | -20°C | | solubility | Soluble in DMSO, Ethyl acetate, or Ethanol. | | form | solid | | color | White | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO, ethanol, or ethyl acetate may be stored at -20° for up to 1 month. | | InChIKey | UJNSFDHVIBGEJZ-SQJADDCJSA-N | | SMILES | C/C1=C\CC[C@](O2)(C)[C@@]2([H])[C@@H](OC([C@@H]3CN(C)C)=O)[C@@]3([H])CC1 |
| WGK Germany | WGK 3 | | HS Code | 2932209090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Skin Sens. 1 |
| | DMAPT Usage And Synthesis |
| Description | DMAPT (870677-05-7) is a water soluble analog of the natural plant product parthenolide (Cat.# 10-2096) which suppresses in vivo tumor growth of two tobacco-associated neoplasms, lung and bladder cancer. It inhibits NFκB and stimulates the formation of reactive oxygen species which induced the activation of JNK.1 In non-small cell lung cancers DMAPT inhibits NFκB and DNA double-strand break repair.2 | | Uses | DMAPT is a parthenolide derivative that functions as an antileukemic and cytotoxic agents. | | in vivo | Treatment with DMAPT (100 mg/kg, Oral gavage daily for 7 days) increases sensitivity of PC-3 tumor xenografts to X-rays[2].
DMAPT (100 mg/kg, Oral gavage thrice weekly from 42 to 300 days since birth) treatment slows normal tumor development in TRAMP mice, extending the time-to-palpable prostate tumor by 20%[3].
DMAPT further reduces the metastatic area below that of the water vehicle treatment group in lung tissues (0.10% ± 0.15 SD, 92% reduction, p = 0.0028) in TRAMP mice[3].
| | References | [1] RAJASUBRAMANIAM SHANMUGAM. A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species†[J]. International Journal of Cancer, 2010, 128 10: 2481-2494. DOI:10.1002/ijc.25587
[2] NEIL C. ESTABROOK . Inhibition of NF-κB and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays[J]. Free Radical Biology and Medicine, 2011, 51 12: Pages 2249-2258. DOI:10.1016/j.freeradbiomed.2011.09.029 |
| | DMAPT Preparation Products And Raw materials |
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