- Wnt-C59
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- $33.00
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2026-05-11
- CAS:1243243-89-1
- Purity: 99.95%
- Supply Ability: 10g
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| | Wnt-C59 Basic information |
| Product Name: | Wnt-C59 | | Synonyms: | Wnt-C59;2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetaMide;C59;Wnt-C59 (C59);4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide;4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide Wnt-c59;Wnt-C59, >=98%;WNT-C59 (C59);WNT C59;C59 | | CAS: | 1243243-89-1 | | MF: | C25H21N3O | | MW: | 379.45 | | EINECS: | | | Product Categories: | Inhibitors;API | | Mol File: | 1243243-89-1.mol |  |
| | Wnt-C59 Chemical Properties |
| Melting point | >159°C (dec.) | | Boiling point | 628.3±55.0 °C(Predicted) | | density | 1.198±0.06 g/cm3(Predicted) | | storage temp. | +2C to +8C | | solubility | Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL) | | form | Off-white powder | | pka | 13.78±0.70(Predicted) | | color | Tan | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. | | InChI | InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29) | | InChIKey | KHZOJCQBHJUJFY-UHFFFAOYSA-N | | SMILES | C1(CC(NC2=CC=C(C3=CC=CN=C3)C=C2)=O)=CC=C(C2C=CN=C(C)C=2)C=C1 |
| WGK Germany | WGK 2 | | HS Code | 2933399990 | | Storage Class | 11 - Combustible Solids |
| | Wnt-C59 Usage And Synthesis |
| Description | Wnt-C59 (1243243-89-1) is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase.1 Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms. It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1 Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice.2 Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1).3 Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.4 | | Uses | Wnt-C59 is a porcupine homolog – Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase. | | in vivo | Wnt-C59 displays good bioavailability in mice. Wnt-C59 blocks progression of mammary tumors in MMTV-WNT1 transgenic mice while downregulating Wnt/β-catenin target genes[1]. Wnt-C59 has the potential to eradicate cancer stem cells in human tumors. Wnt-C59 inhibits stemness properties of NPC cells in a dosage-dependent manner by arresting sphere formation in both HNE1 and SUNE1 cells[2]. | | storage | -20°C | | References | [1] KYLE DAVID PROFFITT. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.[J]. Cancer research, 2013, 73 2: 502-507. DOI:10.1158/0008-5472.can-12-2258
[2] BON-KYOUNG KOO. Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 24: 7548-7550. DOI:10.1073/pnas.1508113112
[3] M. MOTONO. WNT‐C59, a Small‐Molecule WNT Inhibitor, Efficiently Induces Anterior Cortex That Includes Cortical Motor Neurons From Human Pluripotent Stem Cells[J]. Stem Cells Translational Medicine, 2016, 5 1. DOI:10.5966/sctm.2015-0261
[4] BABITA MADAN . Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis[J]. Kidney international, 2016, 89 5: Pages 1062-1074. DOI:10.1016/j.kint.2016.01.017 |
| | Wnt-C59 Preparation Products And Raw materials |
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