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Streptochlorin manufacturers
- Streptochlorin
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2026-07-10
- CAS:120191-51-7
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1000kg
- Streptochlorin
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- $2110.00
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2026-04-21
- CAS:120191-51-7
- Purity:
- Supply Ability: 10g
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| | Streptochlorin Basic information |
| Product Name: | Streptochlorin | | Synonyms: | Streptochlorin;3-(4-Chloro-5-oxazolyl)-1H-indole;Antibiotic SF 2583A;SF 2583A;1H-Indole, 3-(4-chloro-5-oxazolyl)-;4-Chloro-5-(1H-indol-3-yl)oxazole;Streptochlorin, Antiangiogenic agent | | CAS: | 120191-51-7 | | MF: | C11H7ClN2O | | MW: | 218.63908 | | EINECS: | | | Product Categories: | | | Mol File: | 120191-51-7.mol |  |
| | Streptochlorin Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: soluble; Methanol: soluble | | form | A solid | | color | Crystalline |
| | Streptochlorin Usage And Synthesis |
| Description | Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 20 μM. Streptochlorin (12 μg/ml) decreases viability of, as well as induces apoptosis and increases the production of reactive oxygen species (ROS) in, Hep3B human hepatocellular carcinoma cells. It does not induce cytotoxicity in RBL-2H3 mast cells at concentrations up to 100 μM. Streptochlorin prevents degranulation in antigen-stimulated mast cells, as well as inhibits Syk kinase and the Src family kinases LYN and Fyn and reduces the secretion of TNF-α and IL-4 induced by dinitrophenyl-human serum album (DNP-HSA) in RBL-2H3 mast cells. It also decreases swelling and reduces scratching behavior in a mouse model of allergic dermatitis induced by dinitrofluorobenzene (DNFB). | | Uses | Streptochlorin is an antineoplastic agent and a potential chemotherapeutic agent for treating cholangiocarcinoma. | | storage | +4°C | | References | [1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] IN-KWON CHOI. Streptochlorin, a marine natural product, inhibits NF-kappaB activation and suppresses angiogenesis in vitro.[J]. Journal of microbiology and biotechnology, 2007, 17 8: 1338-1343.
[3] DONG YEOK SHIN. Streptochlorin isolated from Streptomyces sp. Induces apoptosis in human hepatocarcinoma cells through a reactive oxygen species-mediated mitochondrial pathway.[J]. Journal of microbiology and biotechnology, 2008, 18 11: 1862-1868. DOI: 10.4014/jmb.0800.124
[4] SEUNG-HWAN LEE. Streptochlorin suppresses allergic dermatitis and mast cell activation via regulation of Lyn/Fyn and Syk signaling pathways in cellular and mouse models.[J]. PLoS ONE, 2013: e74194. DOI: 10.1371/journal.pone.0074194 |
| | Streptochlorin Preparation Products And Raw materials |
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