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| | 4-PhenylpyriMidine-2-carboxylic acid Basic information |
| | 4-PhenylpyriMidine-2-carboxylic acid Chemical Properties |
| Melting point | 154-156 °C(Solv: benzene (71-43-2)) | | Boiling point | 468.2±38.0 °C(Predicted) | | density | 1.302±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 3.02±0.10(Predicted) |
| | 4-PhenylpyriMidine-2-carboxylic acid Usage And Synthesis |
| Synthesis | 4-Substituted phenylpyrimidine-2-carboxamide (0.025 mol) was mixed with 20% sulfuric acid solution (100 mL) and the reaction was heated at 100 °C for 5-10 h. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was poured into an ice/water mixture under vigorous stirring, followed by collection of the precipitate by filtration and drying to give 4-substituted phenylpyrimidine-2-carboxylic acid as a light yellow solid. | | References | [1] European Journal of Medicinal Chemistry, 2013, vol. 69, p. 77 - 89
[2] Patent: CN104072480, 2016, B. Location in patent: Paragraph 0239; 0240
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 23, p. 6166 - 6173 |
| | 4-PhenylpyriMidine-2-carboxylic acid Preparation Products And Raw materials |
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