- 3-methyl-p-anisidine
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- $100.00
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2024-04-23
- CAS:136-90-3
- Min. Order: 1kg
- Purity: 99.93%
- Supply Ability: 1000kg per week
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| | 4-methoxy-3-methylaniline Basic information |
| Product Name: | 4-methoxy-3-methylaniline | | Synonyms: | 4-AMino-2-Methylanisole[4-Methoxy-3-Methylaniline];3-Methyl-4-methoxybenzenamine;4-AMINO-2-METHYLANISOLE;4-METHOXY-3-METHYLANILINE;3-Methyl-4-methoxyaniline;4-methoxy-3-methylbenzenamine;BenzenaMine, 4-Methoxy-3-Methyl-;4-AMINO-24-AMINO-2-METHYLANISOLE-METHYLANISOLE | | CAS: | 136-90-3 | | MF: | C8H11NO | | MW: | 137.18 | | EINECS: | | | Product Categories: | | | Mol File: | 136-90-3.mol |  |
| | 4-methoxy-3-methylaniline Chemical Properties |
| Melting point | 57-60℃ | | Boiling point | 252.03°C (rough estimate) | | density | 1.0630 (rough estimate) | | refractive index | 1.5360 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | pka | 5.32±0.10(Predicted) | | color | Dark Red to Black | | InChI | 1S/C8H11NO/c1-6-5-7(9)3-4-8(6)10-2/h3-5H,9H2,1-2H3 | | InChIKey | NFWPZNNZUCPLAX-UHFFFAOYSA-N | | SMILES | COc1ccc(N)cc1C |
| Hazard Codes | Xn | | Risk Statements | 20/21/22-36/37/38 | | Safety Statements | 26-36/37/39 | | WGK Germany | 3 | | HS Code | 2922290090 | | Storage Class | 13 - Non Combustible Solids | | Hazard Classifications | Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 4-methoxy-3-methylaniline Usage And Synthesis |
| Uses | 4-Methoxy-3-methylaniline is used in preparation of triamine pyrimidine derivatives as antitumor agents. | | Synthesis | The synthesis of 4-methoxy-3-methylaniline is as follows:
4-Methoxy-3-methyl-phenylamine10% Palladium on carbon (10% Pd/C) (1.5 g) was added to a solution of 1 -methoxy-2- methyl-4-nitrobenzene (9.5 g, 57 mmol) in methanol (100 ml_). The mixture was stirred under a hydrogen atmosphere (1 atm.) at room temperature for 16 h. The mixture was filtered through a pad of CELITE and the filtrate was evaporated in vacuo to yield 4- methoxy-3-methylphenylamine (8.0 g, 57 mmol, 100%).
 | | References | [1] Patent: WO2006/95014, 2006, A1. Location in patent: Page/Page column 33
[2] Angewandte Chemie - International Edition, 2017, vol. 56, # 21, p. 5886 - 5889
[3] Angew. Chem., 2017, vol. 129, p. 5980 - 5983,4
[4] Synthesis, 1995, # 4, p. 397 - 408
[5] Journal of the American Chemical Society, 1946, vol. 68, p. 1551 |
| | 4-methoxy-3-methylaniline Preparation Products And Raw materials |
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