1221158-13-9
| 中文名称 | 1221158-13-9 |
|---|---|
| 中文同义词 | 硫酸阿卡波糖;化合物 T22541;化合物 ACARBOSE SULFATE;阿卡波糖杂质11 |
| 英文名称 | Acarbose (sulfate) |
| 英文同义词 | Acarbose (sulfate);Acarbose Impurity 11 |
| CAS号 | 1221158-13-9 |
| 分子式 | C25H45NO22S |
| 分子量 | 743.68 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1221158-13-9.mol |
| 结构式 |  |
1221158-13-9 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
Acarbose (1, 2, and 3 μM) dose- and time-dependently inhibits TNF-α-induced VSMC proliferation and migration. Acarbose (1, 2, and 3 μM) dose-dependently decreases β-galactosidase, Ras expression and increased p-AMPK expression in TNF-α pre-treated A7r5 cells.
Acarbose (300 mg/60 kg body weight) decreases the fasting blood glucose, and regulates the glucose tolerance of DM rats without body weight loss. Acarbose significantly suppresses serum IL6 and TNF-α in DM rats. Acarbose (2.5 and 5.0 mg/kg) significantly and dose-dependently decreases the intensity of neointimal IL-6, TNF-α, and iNOS staining, and significantly increases the intensity of neointimal p-AMPK staining. Acarbose (2.5 and 5.0 mg/kg) significantly and dose-dependently decreases neointimal Ras and β-galactosidase expression in HCD-fed rabbits without body weight loss.