- Y-320
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- $39.00 / 1mg
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2025-04-29
- CAS:288250-47-5
- Min. Order:
- Purity: 99.23%
- Supply Ability: 10g
- Y320
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- $5.00 / 5KG
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2019-09-04
- CAS:288250-47-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1ton
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| Product Name: | Y320 | | Synonyms: | Y320;1-(4-CHLOROPHENYL)-N-(3-CYANO-4-(4-MORPHOLINOPIPERIDIN-1-YL)PHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE;1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide;1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-car;1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide Y320;Y320 1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide;Y-320, >=98%;1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxami | | CAS: | 288250-47-5 | | MF: | C27H29ClN6O2 | | MW: | 505.01 | | EINECS: | 200-256-5 | | Product Categories: | Inhibitors | | Mol File: | 288250-47-5.mol |  |
| Boiling point | 631.2±55.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | ≥24.8 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH | | form | solid | | pka | 11.82±0.70(Predicted) | | color | Off-white to pink |
| Description | Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM. | | In vitro | Y-320 also inhibits the production of IFN-γ and TNF-α by mouse CD4 T cells stimulated with IL-15, CXCL12, and anti-CD3 mAb. | | In vivo | Y-320 (0.3-3 mg/kg p.o.) ameliorates collagen-induced arthritis (CIA) in Mice with a reduction of IL-17 mRNA in arthritic joints, and also shows therapeutic effects on CIA in cynomolgus monkeys. Moreover, Y-320 shows a synergistic effect in combination with anti-TNF-α mAb on chronic-progressing CIA in mice. | | Uses | 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide inhibits T cell activation induced by IL-15 and shows a therapeutic effect on collagen-induced arthritis in DBA/1J mice. | | Biological Activity | y-320 is a new phenylpyrazoleanilide immunomodulator [1].immunotherapy refers to treatment of disease by suppressing, inducing or enhancing an immune response.y-320 is a new phenylpyrazoleanilide immunomodulator. y-320 inhibited il-17 production by cd4 t cells induced by il-15 with ic50 values of 20-60 nm [1].in type ii collagen-induced arthritis (cia) mice, oral administration of y-320 (0.3-3 mg/kg) reduced il-17 mrna expression and significantly inhibited the development of joint destruction and arthritis. the combination of y-320 with anti-murine tumor necrosis factor-α (tnf-α) monoclonal antibody exhibited a synergistic effect. in cynomolgus monkeys, y-320 (0.3-1 mg/kg) relieved cia. these results suggested that y-320 could be a useful candidate for therapy of rheumatoid arthritis (ra) [1]. | | in vivo | Y-320 (0-3 mg/kg; p.o.; daily, for 42 d) ameliorates collagen-induced arthritis (CIA) in DBA/1J mice with a reduction of IL-17 mRNA in arthritic joints[1].
Y-320 (5 mg/kg; i.v.; every three days, for 18 d; Homozygous nude athymic mice with Bats-72 xenograft) sensitizes MDR xenograft tumor to Paclitaxel in vivo[3]. | Animal Model: | Type II collagen-induced arthritis (CIA) in DBA/1J mice[1] | | Dosage: | 0, 0.1, 0.3, 1, and 3 mg/kg | | Administration: | Oral administration; daily, for 42 days | | Result: | Inhibited the development of CIA and the increase in paw thickness in a dose-dependent manner.
Inhibited joint destructions in a dose-dependent manner.
Improved inflammation and damage in the arthritic ankle joints in CIA mice.
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| Animal Model: | Homozygous nude athymic mice with Bats-72 xenograft (female, 4-5 weeks old)[3] | | Dosage: | 5 mg/kg; Paclitaxel (5 mg/kg) | | Administration: | Intravenous injection; every three days, for 18 days | | Result: | Inhibited tumor growth in Bats-72 xenografts without severe adverse effects.
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| | IC 50 | IL-15; IL-17 | | references | [1]. ushio h, ishibuchi s, oshita k, et al. a new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. pharmaceuticals (basel), 2013, 7(1): 1-17. |
| | Y320 Preparation Products And Raw materials |
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