N-乙酰-2-苄基色胺
| 中文名称 | N-乙酰-2-苄基色胺 |
|---|---|
| 中文同义词 | N-乙酰-2-苄基色胺溶液,100PPM;N-乙酰基-2-苄基色胺;N-(2-(2-苄基-1H-吲哚-3-基)乙基)乙酰胺;N-[2-[2-(苯基甲基)-1H-吲哚-3-基]乙基]乙酰胺;N-乙酰-2-苄基色胺;褪黑素受体拮抗剂;LUZINDOLE N-乙酰基-2-苄基色胺;LUZINDOLE (N-0774),MELATONIN RECEPTOR拮抗剂 |
| 英文名称 | LUZINDOLE |
| 英文同义词 | LUZINDOLE;n-[2-[2-(phenylmethyl)-1h-indol-3-yl]ethyl]acetamide;N-[2-[2-(Phenylmethyl)-1H-indol-3-yl]ethyl]acetamide, N-Acetyl-2-benzyltryptamine;N-ACETYL-2-BENZYLTRYPTAMINE;N-0774;LuzindoleN-Acetyl-2-benzyltryptamine;N-(2-(2-benzyl-1H-indol-3-yl)ethyl)acetamide;2-Benzyl-N-acetyltryptaMine |
| CAS号 | 117946-91-5 |
| 分子式 | C19H20N2O |
| 分子量 | 292.37 |
| EINECS号 | |
| 相关类别 | 合成;Melatonin receptor;Aromatics Compounds;Aromatics |
| Mol文件 | 117946-91-5.mol |
| 结构式 |  |
N-乙酰-2-苄基色胺 性质
| 熔点 | 44-46°C |
|---|---|
| 沸点 | 434.31°C (rough estimate) |
| 密度 | 1.1045 (rough estimate) |
| 折射率 | 1.6140 (estimate) |
| 储存条件 | -20°C |
| 溶解度 | 在DMSO中的溶解度为5 毫克/毫升 |
| 形态 | 白色至类白色结晶固体。 |
| 酸度系数(pKa) | 16.36±0.46(Predicted) |
| 颜色 | 灰白色至黄色 |
| 水溶解性 | Soluble in DMSO (100 mM), ethanol (100 mM), chloroform, methanol, and water. |
| 稳定性 | -20°C储存 |
| InChI | 1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22) |
| InChIKey | WVVXBPKOIZGVNS-UHFFFAOYSA-N |
| SMILES | CC(=O)NCCc1c(Cc2ccccc2)[nH]c3ccccc13 |
| CAS 数据库 | 117946-91-5(CAS DataBase Reference) |
Ki :10.2 nM (human MT2), 158 nM (human MT1)
Luzindole (N-0774) (5-10 μg/ml) inhibits antigen-specific proliferation of the MBP-reactive LV-4 T cell line.
Luzindole (N-0774) (30 mg/kg; i.p.; days 0-5) suppresses experimental autoimmune encephalomyelitis.
Luzindole (N-0774) (30 mg/kg i.p.) reduces the time of immobility in a dose-dependent manner, the effect being more pronounced at midnight (60% reduction) than at noon (39% reduction). The effect of luzindole is time-dependent, showing a maximal effect at 60 min. The anti-immobility effect of luzindole (10 mg/kg i.p.) is prevented by the administration of melatonin (30 mg/kg i.p.). Luzindole (30 mg/kg i.p.) did not modify the time of immobility either at noon or midnight in the albino ND/4 mouse, or in the C57BL/6J mouse, which does not produce melatonin.
| Animal Model: | Twenty-three- to 12-week-old(SJL X PL/J ) F1 mice |
| Dosage: | 30 mg/kg |
| Administration: | i.p.; days 0-5 (between 23: 00 and 1: 00 under conditions of minimal lighting) |
| Result: | Effectively prevented experimental autoimmune encephalomyelitis. |
安全信息
| 安全说明 | 24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS号 | AC7765700 |
| 海关编码 | 29339980 |
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
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英文
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-101254 | N-乙酰-2-苄基色胺 Luzindole | 117946-91-5 | 1mg | 760元 |
| 2025/12/22 | HY-101254 | N-乙酰-2-苄基色胺 Luzindole | 117946-91-5 | 5mg | 1900元 |