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| | 1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[biotinyl(polyethylene glycol)-2000] (aMMoniuM salt) Basic information |
| Product Name: | 1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[biotinyl(polyethylene glycol)-2000] (aMMoniuM salt) | | Synonyms: | 1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[biotinyl(polyethylene glycol)-2000] (aMMoniuM salt);DSPE-PEG(2000) Biotin;1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-[BIOTINYL(POLYETHYLENE GLYCOL)-2000] (AMMONIUM SALT);DSPE-PEG(2000) BIOTIN;DSPE-PEG-2K-Biotin;1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[biotinyl(polyethylene glycol)-2000] (aMMoniuM salt) ISO 9001:2015 REACH;DSPE-PEG-Biotin (MW 2000);DSPE-MPEG-2000-Biotin;DSPEPEGBiotin (MW 2000),DSPE PEG Biotin (MW 2000) | | CAS: | 385437-57-0 | | MF: | (C2H4O)nC54H101N4O12PS.Na | | MW: | 0 | | EINECS: | | | Product Categories: | peg | | Mol File: | 385437-57-0.mol | ![1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[biotinyl(polyethylene glycol)-2000] (aMMoniuM salt) Structure](CAS/20240320/GIF/385437-57-0.gif) |
| | 1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[biotinyl(polyethylene glycol)-2000] (aMMoniuM salt) Chemical Properties |
| storage temp. | -20°C | | solubility | Ethanol: Soluble: =10 mg/ml | | form | Solid | | color | White to off-white |
| WGK Germany | WGK 3 | | Hazard Classifications | Acute Tox. 3 Inhalation Acute Tox. 4 Oral Aquatic Chronic 3 Carc. 2 Eye Irrit. 2 Repr. 2 Skin Irrit. 2 STOT RE 1 STOT SE 3 |
| | 1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[biotinyl(polyethylene glycol)-2000] (aMMoniuM salt) Usage And Synthesis |
| Description | DSPE-PEG-Biotin, MW 2,000 is a biotin amphipilic material which forms micelles in an aqueous solution and binds selectively with streptavidin and avidin. This polymer is very promising nanocarriers for therapeutic drug delivery, imaging and molecular labeling. | | Uses | DSPE-PEG-Biotin, MW 1000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 [2] ZHANG J, LUO Y, ZHAO X, et al. Co-delivery of doxorubicin and the traditional Chinese medicine quercetin using biotin–PEG2000–DSPE modified liposomes for the treatment of multidrug resistant breast cancer[J]. RSC Advances, 2016, 114: 113173-113184. DOI: 10.1039/c6ra24173e [3] DONGHUA LIU. Tumor Specific Delivery and Therapy by Double-Targeted Nanostructured Lipid Carriers with Anti-VEGFR-2 Antibody[J]. Molecular Pharmaceutics, 2011, 8 6: 2291-2301. DOI: 10.1021/mp200402e [4] JAKOB WALLNER. An approach for liposome immobilization using sterically stabilized micelles (SSMs) as a precursor for bio-layer interferometry-based interaction studies[J]. Colloids and Surfaces B: Biointerfaces, 2017, 154: Pages 186-194. DOI: 10.1016/j.colsurfb.2017.03.015 |
| | 1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[biotinyl(polyethylene glycol)-2000] (aMMoniuM salt) Preparation Products And Raw materials |
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