| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
FTI-2153 manufacturers
- FTI-2153
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- $2810.00
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2026-07-15
- CAS:344900-92-1
- Purity:
- Supply Ability: 10g
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| | FTI-2153 Basic information |
| Product Name: | FTI-2153 | | Synonyms: | FTI-2153;L-Methionine, N-[[5-[[(1H-imidazol-5-ylmethyl)amino]methyl]-2'-methyl[1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester;L-Methionine,N-[[5-[[(1H-imidazol-4-ylmethyl)amino]methyl]-2'-methyl[1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester;FTI2153,FTI 2153 | | CAS: | 344900-92-1 | | MF: | C25H30N4O3S | | MW: | 466.6 | | EINECS: | | | Product Categories: | | | Mol File: | 344900-92-1.mol |  |
| | FTI-2153 Chemical Properties |
| Boiling point | 700.1±60.0 °C(Predicted) | | density | 1.210±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 100 mg/mL (214.32 mM) | | pka | 13.00±0.46(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | FTI-2153 Usage And Synthesis |
| Uses | FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC50 of 1.4 nM. FTI-2153 is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing. Anti-cancer activity[1]. | | References | [1] Sun J, et al. Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine. Cancer Res. 1999 Oct 1;59(19):4919-26. PMID:10519405
[2] N C Crespo, et al. The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status. Cell Death Differ. 2002 Jul;9(7):702-9. DOI:10.1038/sj.cdd.4401023 |
| | FTI-2153 Preparation Products And Raw materials |
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