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| | 1-(5-BroMo-2-Methoxypyridin-3-yl)ethanone Basic information |
| Product Name: | 1-(5-BroMo-2-Methoxypyridin-3-yl)ethanone | | Synonyms: | 1-(5-BroMo-2-Methoxypyridin-3-yl)ethanone;Ethanone, 1-(5-bromo-2-methoxy-3-pyridinyl)-;1-(5-Bromo-2-methoxypyridin-3-yl)ethan-1-one;1-(5-Bromo-2-methoxy-3-pyridyl)ethanone;1-(5-Bromo-2-methoxypyridin-3-yl)ethan-1-one - [B72418] | | CAS: | 1256811-02-5 | | MF: | C8H8BrNO2 | | MW: | 230.06 | | EINECS: | | | Product Categories: | | | Mol File: | 1256811-02-5.mol |  |
| | 1-(5-BroMo-2-Methoxypyridin-3-yl)ethanone Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | White to off-white Solid |
| | 1-(5-BroMo-2-Methoxypyridin-3-yl)ethanone Usage And Synthesis |
| Synthesis | Methylmagnesium bromide (MeMgBr, 10 mL, 30.0 mmol) was added slowly and dropwise to a solution of 5-bromo-N,2-dimethoxy-N-methylnicotinamide (5.0 g, 18.18 mmol) in tetrahydrofuran (THF, 50 mL) at -78 °C. The reaction mixture was stirred at 20 °C overnight. Subsequently, the reaction mixture was quenched by pouring into aqueous ammonium chloride (NH4Cl) solution. The mixture was extracted with ethyl acetate (EtOAc). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (eluent: petroleum ether/ethyl acetate=10:1) to afford 1-(5-bromo-2-methoxypyridin-3-yl)ethanone (3.0 g, 71% yield).1H NMR (CDCl3, 400 MHz) δ 8.33 (d, J=2.4Hz, 1H), 8.19 (d, J=2.4Hz, 1H), 4.03 ( s, 3H), 2.63 (s, 3H). Mass spectrum (MS) (M+H)+: 230/232. | | References | [1] Patent: WO2013/33971, 2013, A1. Location in patent: Page/Page column 145
[2] Patent: US2014/213571, 2014, A1. Location in patent: Paragraph 0576 |
| | 1-(5-BroMo-2-Methoxypyridin-3-yl)ethanone Preparation Products And Raw materials |
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