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| | 2-HYDROXYACETOPHENONE Basic information |
| | 2-HYDROXYACETOPHENONE Chemical Properties |
| Melting point | 86-89 °C (lit.) | | Boiling point | 126 °C / 12mmHg | | density | 1.0963 | | refractive index | 1.5470 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 13.09±0.10(Predicted) | | form | Powder | | color | Slightly yellow to orange | | Water Solubility | Soluble in water, ether, ethanol, chloroform. | | Sensitive | Air & Moisture Sensitive | | InChI | 1S/C8H8O2/c9-6-8(10)7-4-2-1-3-5-7/h1-5,9H,6H2 | | InChIKey | ZWVHTXAYIKBMEE-UHFFFAOYSA-N | | SMILES | OCC(=O)c1ccccc1 | | LogP | 0.721 (est) | | CAS DataBase Reference | 582-24-1(CAS DataBase Reference) | | NIST Chemistry Reference | «alpha»-Hydroxyacetophenone(582-24-1) | | EPA Substance Registry System | Ethanone, 2-hydroxy-1-phenyl- (582-24-1) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | TSCA | TSCA listed | | HS Code | 29144000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-HYDROXYACETOPHENONE Usage And Synthesis |
| Chemical Properties | slightly yellow to orange powder | | Uses | 2-Hydroxyacetophenone can be used to produce 2-hydroxy-1-phenyl-ethanone-(1)-oxime by heating. It is used as pharmaceutical intermediate. | | Uses | 2-Hydroxyacetophenone can be used as a starting material for the synthesis of:
- Enantioselective 1R-phenyl-1,2-ethanediol in the presence of a rhodium(III) catalyst by asymmetric transfer hydrogenation.
- Copper(II) complexes of 2-hydroxyacetophenone N-substituted thiosemicarbazones.
- Chromium, molybdenum, and ruthenium complexes of 2-hydroxyacetophenone Schiff bases.
- 2-Hydroxyacetophenone-aroyl hydrazone derivatives for inhibition of copper corrosion in nitric acid.
| | Definition | ChEBI: 2-hydroxyacetophenone is a monohydroxyacetophenone that is acetophenone in which one of the methyl hydrogens has been replaced by a hydroxy group. It is a primary alcohol, a primary alpha-hydroxy ketone and a monohydroxyacetophenone. | | Synthesis | Add 20 mmol of 48% hydrobromic acid to a 500 mL three-necked flask containing 20 mmol of styrene and 100 mL of water at room temperature, and slowly add 200 mmol of .
30% hydrogen peroxide, control the drip time for 30min, stir at room temperature for 30min, heat up to 80 , the reaction was 10h.
C, the reaction was carried out for 10 h. The organic and aqueous phases were separated by standing. The organic phase containing 2-bromoacetophenone was added to a reactor containing 150 mL of water .
The organic phase containing 2-bromoacetophenone was added to a reactor containing 150 mL of water , and hydrolyzed completely under the promotion of microwave, and the organic and aqueous phases were separated by standing to obtain a solution of 2-hydroxyacetophenone. | | IC 50 | HIV |
| | 2-HYDROXYACETOPHENONE Preparation Products And Raw materials |
| Preparation Products | 1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)-
Piperidine, 1-(oxophenylacetyl)- (9CI)-->Ethyl benzoate-->2-Bromo-2′-hydroxyacetophenone-->1-Phenyl-1,2-ethanediol-->1H-Pyrazole-3-carboxylic acid, 5-(2-hydroxyphenyl)-, ethyl ester-->4-Phenyloxazole-2-thiol-->Methanesulfonic acid, 1,1,1-trifluoro-, 2-oxo-2H-1-benzopyran-4-yl ester |
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